Cathartic effect of the leaf extract of Vernonia amygdalina

S. O. Awe, J. M. Makinde, O. A. Olajide

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


A methanol extract of Vernonia amygdalina leaves was evaluated for cathartic effect. The extract exhibited a significant promotion of intestinal motility on charcoal meal test in mice. Frequency of defecation and of faeces were markedly increased following administration of the extract which also promoted gastric emptying in rats. Preliminary studies on the isolated rat fundus strip showed a contractile effect, which was blocked by atropine.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
Issue number2
Publication statusPublished - 1 Apr 1999
Externally publishedYes


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