Cathartic effect of the leaf extract of Vernonia amygdalina

S. O. Awe; J. M. Makinde; O. A. Olajide

doi:10.1016/S0367-326X(99)00017-9

Cathartic effect of the leaf extract of Vernonia amygdalina

S. O. Awe, J. M. Makinde, O. A. Olajide

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A methanol extract of Vernonia amygdalina leaves was evaluated for cathartic effect. The extract exhibited a significant promotion of intestinal motility on charcoal meal test in mice. Frequency of defecation and of faeces were markedly increased following administration of the extract which also promoted gastric emptying in rats. Preliminary studies on the isolated rat fundus strip showed a contractile effect, which was blocked by atropine.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Fitoterapia
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/S0367-326X(99)00017-9
Publication status	Published - 1 Apr 1999
Externally published	Yes

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10.1016/S0367-326X(99)00017-9

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title = "Cathartic effect of the leaf extract of Vernonia amygdalina",

abstract = "A methanol extract of Vernonia amygdalina leaves was evaluated for cathartic effect. The extract exhibited a significant promotion of intestinal motility on charcoal meal test in mice. Frequency of defecation and of faeces were markedly increased following administration of the extract which also promoted gastric emptying in rats. Preliminary studies on the isolated rat fundus strip showed a contractile effect, which was blocked by atropine.",

keywords = "Contractile effect, Gastric emptying, Intestinal motility, Vernonia amygdalina",

author = "Awe, {S. O.} and Makinde, {J. M.} and Olajide, {O. A.}",

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AU - Awe, S. O.

AU - Makinde, J. M.

AU - Olajide, O. A.

PY - 1999/4/1

Y1 - 1999/4/1

N2 - A methanol extract of Vernonia amygdalina leaves was evaluated for cathartic effect. The extract exhibited a significant promotion of intestinal motility on charcoal meal test in mice. Frequency of defecation and of faeces were markedly increased following administration of the extract which also promoted gastric emptying in rats. Preliminary studies on the isolated rat fundus strip showed a contractile effect, which was blocked by atropine.

AB - A methanol extract of Vernonia amygdalina leaves was evaluated for cathartic effect. The extract exhibited a significant promotion of intestinal motility on charcoal meal test in mice. Frequency of defecation and of faeces were markedly increased following administration of the extract which also promoted gastric emptying in rats. Preliminary studies on the isolated rat fundus strip showed a contractile effect, which was blocked by atropine.

KW - Contractile effect

KW - Gastric emptying

KW - Intestinal motility

KW - Vernonia amygdalina

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U2 - 10.1016/S0367-326X(99)00017-9

DO - 10.1016/S0367-326X(99)00017-9

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SP - 161

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JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 2

ER -

Cathartic effect of the leaf extract of Vernonia amygdalina

Abstract

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