Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Paola Perego, Georg Hempel, Stig Linder, Tracey D. Bradshaw, Annette K. Larsen, Godefridus J. Peters, Roger M. Phillips

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

An increasing number of manuscripts focus on the in vitro evaluation of established and novel anti-tumor agents in experimental models. Whilst the design of such in vitro assays is inherently flexible, some of these studies lack the minimum information necessary to critically evaluate their relevance or have been carried out under unsuitable conditions. The use of appropriate and robust methods and experimental design has important implications for generating results that are reliable, relevant, and reproducible. The Pharmacology and Molecular Mechanisms (PAMM) group of the European Organization for Research and Treatment of Cancer (EORTC) is the largest group of academic scientists working on drug development and bundle decades of expertise in this field. This position paper addresses all researchers with an interest in the preclinical and cellular pharmacology of anti-tumor agents and aims at generating basic recommendations for the correct use of compounds to be tested for anti-tumor activity using a range of preclinical cellular models of cancer.

Original languageEnglish
Pages (from-to)427-441
Number of pages15
JournalCancer Chemotherapy and Pharmacology
Volume81
Issue number3
Early online date28 Dec 2017
DOIs
Publication statusPublished - 1 Mar 2018

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