CFD-DNS simulation of irregular-shaped particle dissolution

Hui Cao, Xiaodong Jia, Yongliang Li, Carlos Amador, Yulong Ding

Research output: Contribution to journalArticlepeer-review

Abstract

A coupled approach between the conventional computational fluid dynamics platform COMSOL and an in-house-developed direct numerical simulation code DigiDiss is presented to study the dissolution kinetics of an irregular-shaped particle in a stirred cuvette. The complex flow dynamics from COMSOL were imported into DigiDiss as an initial flow condition. A digitised 3D particle structure scanned and reconstructed by X-ray micro-tomography was used in the dissolution simulation. A quantitative assessment of the simulation results was made using as a reference experimental data and a theoretical calculation based on the shrinking spherical model with different flow velocity profiles near the particle. The comprehensive agreement demonstrates the coherence of the simulation method in reproducing the experimental behaviour and is seen as a step closer towards developing a computer software design aide to help with formulation development.
Original languageEnglish
Pages (from-to)144-155
Number of pages12
JournalParticuology
Volume50
Early online date24 Oct 2019
DOIs
Publication statusPublished - 1 Jun 2020
Externally publishedYes

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