Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin

Chemistry

• Oxyhemoglobin 100%
• Doxorubicin 78%
• Hemoglobin 69%
• Binding Site 52%
• Drug 39%
• Protein 19%
• Fragmentation 15%
• Thermodynamics 11%
• Mannitol 11%
• Association Constant 9%
• Superoxide 9%
• Fluorescence Spectroscopy 8%
• Molecular Modeling 8%
• Energy Transfer 7%
• Amino Groups 7%
• Circular Dichroism 7%
• Free Radical 7%
• Dose 7%
• Donor 6%
• Force 6%
• Probe 5%
• Fourier Transform Infrared Spectroscopy 5%
• Hydrogen 4%
• Dioxygen 4%
• Mixture 4%
• Acid 3%

Medicine & Life Sciences

• Oxyhemoglobins 98%
• Doxorubicin 69%
• Hemoglobins 60%
• Binding Sites 57%
• Pharmaceutical Preparations 31%
• Thermodynamics 18%
• Proteins 13%
• Energy Transfer 9%
• Fluorescence Spectrometry 9%
• Circular Dichroism 9%
• Hydrogen Bonding 9%
• Static Electricity 8%
• Mannitol 8%
• Fourier Transform Infrared Spectroscopy 8%
• Hydrophobic and Hydrophilic Interactions 8%
• Free Radicals 7%
• Superoxide Dismutase 6%
• Oxygen 5%
• Amino Acids 5%
• Neoplasms 2%