Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin

Chemistry

• Acid 3%
• Amino Groups 7%
• Association Constant 9%
• Binding Site 52%
• Circular Dichroism 7%
• Dioxygen 4%
• Donor 6%
• Dose 7%
• Doxorubicin 78%
• Drug 39%
• Energy Transfer 7%
• Fluorescence Spectroscopy 8%
• Force 6%
• Fourier Transform Infrared Spectroscopy 5%
• Fragmentation 15%
• Free Radical 7%
• Hemoglobin 69%
• Hydrogen 4%
• Mannitol 11%
• Mixture 4%
• Molecular Modeling 8%
• Oxyhemoglobin 100%
• Probe 5%
• Protein 19%
• Superoxide 9%
• Thermodynamics 11%

Medicine & Life Sciences

• Amino Acids 5%
• Binding Sites 57%
• Circular Dichroism 9%
• Doxorubicin 69%
• Energy Transfer 9%
• Fluorescence Spectrometry 9%
• Fourier Transform Infrared Spectroscopy 8%
• Free Radicals 7%
• Hemoglobins 60%
• Hydrogen Bonding 9%
• Hydrophobic and Hydrophilic Interactions 8%
• Mannitol 8%
• Neoplasms 2%
• Oxygen 5%
• Oxyhemoglobins 98%
• Pharmaceutical Preparations 31%
• Proteins 13%
• Static Electricity 8%
• Superoxide Dismutase 6%
• Thermodynamics 18%