Chemical transformations of succinic acid recovered from fermentation broths by a novel direct vacuum distillation-crystallisation method

Rafael Luque, Carol S.K. Lin, Chenyu Du, Duncan J. MacQuarrie, Apostolis Koutinas, Ruohang Wang, Colin Webb, James H. Clark

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

A novel alternative methodology (direct crystallisation) to the traditional calcium precipitation to obtain succinic acid (SA) from defined and wheat-based fermentation broths is reported. SA crystals were successfully recovered from fermentation broths (FB) using this method. A higher SA crystal purity (95%) and yield (70%) were obtained in the direct crystallisation method compared to a slightly modified traditional calcium precipitation method (90% and 24%, respectively). Chemical transformations (e.g. esterifications) to high-added value derivatives of both recovered SA crystals were then investigated using a range of solid acids including our acidic tunable mesoporous carbonaceous materials denoted as Starbon® acids. Results showed that SA crystals could be successfully converted into mono- and diesters in high yields and selectivities employing solid acids regardless of the reaction conditions. The order of reactivity was found to be: pure SA crystals > SA crystals from defined FB > FB SA crystals. Results demonstrate that SA can be effectively purified from actual fermentation broths, showing the importance of integrating the fermentation and downstream processing to optimise the fermentative production of SA and its chemical transformations to produce high-added value derivatives.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalGreen Chemistry
Volume11
Issue number2
Early online date19 Nov 2008
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Succinic Acid
Crystallization
distillation
Distillation
Fermentation
fermentation
crystallization
Vacuum
Acids
acid
Crystals
crystal
method
chemical
Calcium
Derivatives
calcium
Esterification
wheat

Cite this

Luque, Rafael ; Lin, Carol S.K. ; Du, Chenyu ; MacQuarrie, Duncan J. ; Koutinas, Apostolis ; Wang, Ruohang ; Webb, Colin ; Clark, James H. / Chemical transformations of succinic acid recovered from fermentation broths by a novel direct vacuum distillation-crystallisation method. In: Green Chemistry. 2009 ; Vol. 11, No. 2. pp. 193-200.
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abstract = "A novel alternative methodology (direct crystallisation) to the traditional calcium precipitation to obtain succinic acid (SA) from defined and wheat-based fermentation broths is reported. SA crystals were successfully recovered from fermentation broths (FB) using this method. A higher SA crystal purity (95{\%}) and yield (70{\%}) were obtained in the direct crystallisation method compared to a slightly modified traditional calcium precipitation method (90{\%} and 24{\%}, respectively). Chemical transformations (e.g. esterifications) to high-added value derivatives of both recovered SA crystals were then investigated using a range of solid acids including our acidic tunable mesoporous carbonaceous materials denoted as Starbon{\circledR} acids. Results showed that SA crystals could be successfully converted into mono- and diesters in high yields and selectivities employing solid acids regardless of the reaction conditions. The order of reactivity was found to be: pure SA crystals > SA crystals from defined FB > FB SA crystals. Results demonstrate that SA can be effectively purified from actual fermentation broths, showing the importance of integrating the fermentation and downstream processing to optimise the fermentative production of SA and its chemical transformations to produce high-added value derivatives.",
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Chemical transformations of succinic acid recovered from fermentation broths by a novel direct vacuum distillation-crystallisation method. / Luque, Rafael; Lin, Carol S.K.; Du, Chenyu; MacQuarrie, Duncan J.; Koutinas, Apostolis; Wang, Ruohang; Webb, Colin; Clark, James H.

In: Green Chemistry, Vol. 11, No. 2, 2009, p. 193-200.

Research output: Contribution to journalArticle

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