Cholesterol homeostasis: links to hair follicle biology and hair disorders

Megan A Palmer, Liam Blakeborough, Matthew Harries, Iain S Haslam

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

Original languageEnglish
Pages (from-to)299-311
Number of pages13
JournalExperimental Dermatology
Volume29
Issue number3
Early online date1 Jul 2019
DOIs
Publication statusPublished - 1 Mar 2020

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    Palmer, M. A., Blakeborough, L., Harries, M., & Haslam, I. S. (2020). Cholesterol homeostasis: links to hair follicle biology and hair disorders. Experimental Dermatology, 29(3), 299-311. https://doi.org/10.1111/exd.13993