Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity

Panagiotis Zis, André Strydom, David Buckley, Daniel Adekitan, Patrick C. Mchugh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). Methods Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS). Results Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho = −0.517, p = 0.020) and change in the MOMT delayed recall score (Spearman's Rho = −0.577, p = 0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time. Conclusion Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations.
Original languageEnglish
Pages (from-to)254-257
JournalNeuroscience Letters
Volume636
Early online date13 Nov 2016
DOIs
Publication statusPublished - 1 Jan 2017

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Neopterin
Aptitude
Down Syndrome
Cellular Immunity
Vocabulary
Creatinine
Biomarkers
Pteridines
Psychological Adaptation
Cognition
Longitudinal Studies
Alzheimer Disease
Oxidative Stress
Language
Macrophages
Urine
Population

Cite this

Zis, Panagiotis ; Strydom, André ; Buckley, David ; Adekitan, Daniel ; Mchugh, Patrick C. / Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity. In: Neuroscience Letters. 2017 ; Vol. 636. pp. 254-257.
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Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity. / Zis, Panagiotis; Strydom, André; Buckley, David; Adekitan, Daniel; Mchugh, Patrick C.

In: Neuroscience Letters, Vol. 636, 01.01.2017, p. 254-257.

Research output: Contribution to journalArticle

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AU - Mchugh, Patrick C.

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N2 - Background Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). Methods Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS). Results Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho = −0.517, p = 0.020) and change in the MOMT delayed recall score (Spearman's Rho = −0.577, p = 0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time. Conclusion Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations.

AB - Background Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). Methods Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS). Results Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho = −0.517, p = 0.020) and change in the MOMT delayed recall score (Spearman's Rho = −0.577, p = 0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time. Conclusion Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations.

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