Complete Mitochondrial Genome Sequence of the Tyrolean Iceman

Luca Ermini, Cristina Olivieri, Ermanno Rizzi, Giorgio Corti, Raoul Bonnal, Pedro Soares, Stefania Luciani, Isolina Marota, Gianluca De Bellis, Martin B. Richards, Franco Rollo

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.

Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalCurrent Biology
Volume18
Issue number21
Early online date30 Oct 2008
DOIs
Publication statusPublished - 11 Nov 2008
Externally publishedYes

Fingerprint

Mitochondrial Genome
Mitochondrial DNA
Amplification
mitochondrial DNA
Genes
Phylogeography
Ice Cover
Glaciers
Medical Genetics
glaciers
phylogeography
Cadaver
Central European region
human population
Population
Copper
copper
History
Genome
Polymerase Chain Reaction

Cite this

Ermini, L., Olivieri, C., Rizzi, E., Corti, G., Bonnal, R., Soares, P., ... Rollo, F. (2008). Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. Current Biology, 18(21), 1687-1693. https://doi.org/10.1016/j.cub.2008.09.028
Ermini, Luca ; Olivieri, Cristina ; Rizzi, Ermanno ; Corti, Giorgio ; Bonnal, Raoul ; Soares, Pedro ; Luciani, Stefania ; Marota, Isolina ; De Bellis, Gianluca ; Richards, Martin B. ; Rollo, Franco. / Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. In: Current Biology. 2008 ; Vol. 18, No. 21. pp. 1687-1693.
@article{2cc70c761a284388ac40cec79974820f,
title = "Complete Mitochondrial Genome Sequence of the Tyrolean Iceman",
abstract = "The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.",
keywords = "DNA, EVOL_ECOL, HUMDISEASE",
author = "Luca Ermini and Cristina Olivieri and Ermanno Rizzi and Giorgio Corti and Raoul Bonnal and Pedro Soares and Stefania Luciani and Isolina Marota and {De Bellis}, Gianluca and Richards, {Martin B.} and Franco Rollo",
year = "2008",
month = "11",
day = "11",
doi = "10.1016/j.cub.2008.09.028",
language = "English",
volume = "18",
pages = "1687--1693",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "21",

}

Ermini, L, Olivieri, C, Rizzi, E, Corti, G, Bonnal, R, Soares, P, Luciani, S, Marota, I, De Bellis, G, Richards, MB & Rollo, F 2008, 'Complete Mitochondrial Genome Sequence of the Tyrolean Iceman', Current Biology, vol. 18, no. 21, pp. 1687-1693. https://doi.org/10.1016/j.cub.2008.09.028

Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. / Ermini, Luca; Olivieri, Cristina; Rizzi, Ermanno; Corti, Giorgio; Bonnal, Raoul; Soares, Pedro; Luciani, Stefania; Marota, Isolina; De Bellis, Gianluca; Richards, Martin B.; Rollo, Franco.

In: Current Biology, Vol. 18, No. 21, 11.11.2008, p. 1687-1693.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Complete Mitochondrial Genome Sequence of the Tyrolean Iceman

AU - Ermini, Luca

AU - Olivieri, Cristina

AU - Rizzi, Ermanno

AU - Corti, Giorgio

AU - Bonnal, Raoul

AU - Soares, Pedro

AU - Luciani, Stefania

AU - Marota, Isolina

AU - De Bellis, Gianluca

AU - Richards, Martin B.

AU - Rollo, Franco

PY - 2008/11/11

Y1 - 2008/11/11

N2 - The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.

AB - The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.

KW - DNA

KW - EVOL_ECOL

KW - HUMDISEASE

UR - http://www.scopus.com/inward/record.url?scp=55549099553&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2008.09.028

DO - 10.1016/j.cub.2008.09.028

M3 - Article

VL - 18

SP - 1687

EP - 1693

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 21

ER -

Ermini L, Olivieri C, Rizzi E, Corti G, Bonnal R, Soares P et al. Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. Current Biology. 2008 Nov 11;18(21):1687-1693. https://doi.org/10.1016/j.cub.2008.09.028