Complete Mitochondrial Genome Sequence of the Tyrolean Iceman

Luca Ermini, Cristina Olivieri, Ermanno Rizzi, Giorgio Corti, Raoul Bonnal, Pedro Soares, Stefania Luciani, Isolina Marota, Gianluca De Bellis, Martin B. Richards, Franco Rollo

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.

Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalCurrent Biology
Volume18
Issue number21
Early online date30 Oct 2008
DOIs
Publication statusPublished - 11 Nov 2008
Externally publishedYes

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    Ermini, L., Olivieri, C., Rizzi, E., Corti, G., Bonnal, R., Soares, P., Luciani, S., Marota, I., De Bellis, G., Richards, M. B., & Rollo, F. (2008). Complete Mitochondrial Genome Sequence of the Tyrolean Iceman. Current Biology, 18(21), 1687-1693. https://doi.org/10.1016/j.cub.2008.09.028