Compounds with larger heterocyclic rings: Seven-membered ring compounds with two or more different elements in the ring

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews heterocyclic chemistry published in 1996 and covers the literature from 1982-1995. Seven membered rings with two or more heteroatoms are also discussed in the chapter. . Ring closure of the 9-(2, 3-isopropylidene-2, 3, 4-trihydroxybutyl)-8- bromo adenine with concentrated ammonia, Nail or KOtBu gave the corresponding 1, 3-oxazepino[2, 3-e]adenines. The attempted oxidation of the alkaloid with dimethyl sulphoxide/pyridine-sulphur trioxide complex, furnished the 1, 3-oxazepine. The compounds of oxadiazepines are presented with structure diagrams and equations. The chapter is further divided into synthesis/chemistry and applications/biology of 1, 4-oxazepines. It provides details of compounds that have rings containing oxygen and sulphur. Carbohydrate chiral pool based chiral auxiliaries are utilized in an asymmetric Darzen's approach to the enantioselective synthesis of the diltiazem ring system. Selenium and tellurium containing systems are also described.
Original languageEnglish
Title of host publicationSecond Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds
Subtitle of host publicationA Modern Comprehensive Treatise
EditorsMalcolm Sainsbury
PublisherElsevier Science B.V.
Pages233-297
Number of pages65
Volume4
Edition2
ISBN (Print)9780444533470
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes

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    Hemming, K. (2008). Compounds with larger heterocyclic rings: Seven-membered ring compounds with two or more different elements in the ring. In M. Sainsbury (Ed.), Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise (2 ed., Vol. 4, pp. 233-297). Elsevier Science B.V.. https://doi.org/10.1016/B978-044453347-0.50393-1