This chapter reviews heterocyclic chemistry published in 1996 and covers the literature from 1982-1995. Seven membered rings with two or more heteroatoms are also discussed in the chapter. . Ring closure of the 9-(2, 3-isopropylidene-2, 3, 4-trihydroxybutyl)-8- bromo adenine with concentrated ammonia, Nail or KOtBu gave the corresponding 1, 3-oxazepino[2, 3-e]adenines. The attempted oxidation of the alkaloid with dimethyl sulphoxide/pyridine-sulphur trioxide complex, furnished the 1, 3-oxazepine. The compounds of oxadiazepines are presented with structure diagrams and equations. The chapter is further divided into synthesis/chemistry and applications/biology of 1, 4-oxazepines. It provides details of compounds that have rings containing oxygen and sulphur. Carbohydrate chiral pool based chiral auxiliaries are utilized in an asymmetric Darzen's approach to the enantioselective synthesis of the diltiazem ring system. Selenium and tellurium containing systems are also described.
|Title of host publication||Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds|
|Subtitle of host publication||A Modern Comprehensive Treatise|
|Publisher||Elsevier Science B.V.|
|Number of pages||65|
|Publication status||Published - 1 Dec 2008|
Hemming, K. (2008). Compounds with larger heterocyclic rings: Seven-membered ring compounds with two or more different elements in the ring. In M. Sainsbury (Ed.), Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise (2 ed., Vol. 4, pp. 233-297). Elsevier Science B.V.. https://doi.org/10.1016/B978-044453347-0.50393-1