Continuous-Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications

Mohamed Elsherbini, Bethan Winterson, Haifa Alharbi, Ana A. Folgueiras‐Amador, Célina Génot, Thomas Wirth

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An efficient and reliable electrochemical generator of hypervalent iodine reagents has been developed. In the anodic oxidation of iodoarenes to hypervalent iodine reagents under flow conditions, the use of electricity replaces hazardous and costly chemical oxidants. Unstable hypervalent iodine reagents can be prepared easily and coupled with different substrates to achieve oxidative transformations in high yields. The unstable, electrochemically generated reagents can also easily be transformed into classic bench‐stable hypervalent iodine reagents through ligand exchange. The combination of electrochemical and flow‐chemistry advantages largely improves the ecological footprint of the overall process compared to conventional approaches.
Original languageEnglish
Pages (from-to)9811-9815
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number29
Early online date3 May 2019
DOIs
Publication statusPublished - 15 Jul 2019
Externally publishedYes

    Fingerprint

Cite this