CuI-catalyzed cycloisomerization of propargyl amides

Ali Alhalib, Wesley J Moran

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidized to the ketone under the reaction conditions.

Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number5
DOIs
Publication statusPublished - 7 Feb 2014

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