Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Amir  Jalil; Rafieh Bagherifar; Ali Nokhodchi; Barbara Conway; Yousef Javadzadeh

doi:10.34172/apb.2023.087

Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

Amir Jalil, Rafieh Bagherifar, Ali Nokhodchi, Barbara Conway, Yousef Javadzadeh

Research output: Contribution to journal › Review article › peer-review

Abstract

Phytomedicine has been used by humans since ancient times to treat a variety of diseases. However, the use of herbal medicines faces great challenges such as poor water and lipid solubility and instability, which lead to low bioavailability and insufficient therapeutic efficacy. Recently, it has been shown that nanotechnology-based drug delivery systems are appropriate to overcome the above-mentioned limitations. The present review first discusses herbal medicines and the challenges involved in formulation of these drugs. The different types of nano-based drug delivery systems used in herbal delivery and their potential to improve therapeutic efficacy are summarized and common techniques for preparing nanocarriers used in herbal drug delivery are also discussed. Finally, a list of nanophytomedicines that have entered clinical trials since 2010, as well as those that have been approved by the FDA, is presented.

Original language	English
Journal	Advanced Pharmaceutical Bulletin
DOIs	https://doi.org/10.34172/apb.2023.087
Publication status	Accepted/In press - 17 Jul 2023

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10.34172/apb.2023.087Licence: CC BY

Cite this

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title = "Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines",

abstract = "Phytomedicine has been used by humans since ancient times to treat a variety of diseases. However, the use of herbal medicines faces great challenges such as poor water and lipid solubility and instability, which lead to low bioavailability and insufficient therapeutic efficacy. Recently, it has been shown that nanotechnology-based drug delivery systems are appropriate to overcome the above-mentioned limitations. The present review first discusses herbal medicines and the challenges involved in formulation of these drugs. The different types of nano-based drug delivery systems used in herbal delivery and their potential to improve therapeutic efficacy are summarized and common techniques for preparing nanocarriers used in herbal drug delivery are also discussed. Finally, a list of nanophytomedicines that have entered clinical trials since 2010, as well as those that have been approved by the FDA, is presented.",

keywords = "Phytomedicine, Herbal drug, Nanotechnology, Drug delivery systems, Nanophytomedicine",

author = "Amir Jalil and Rafieh Bagherifar and Ali Nokhodchi and Barbara Conway and Yousef Javadzadeh",

year = "2023",

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doi = "10.34172/apb.2023.087",

language = "English",

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T1 - Current Advances in Nanotechnology-Mediated Delivery of Herbal and Plant-Derived Medicines

AU - Jalil, Amir

AU - Bagherifar, Rafieh

AU - Nokhodchi, Ali

AU - Conway, Barbara

AU - Javadzadeh, Yousef

PY - 2023/7/17

Y1 - 2023/7/17

N2 - Phytomedicine has been used by humans since ancient times to treat a variety of diseases. However, the use of herbal medicines faces great challenges such as poor water and lipid solubility and instability, which lead to low bioavailability and insufficient therapeutic efficacy. Recently, it has been shown that nanotechnology-based drug delivery systems are appropriate to overcome the above-mentioned limitations. The present review first discusses herbal medicines and the challenges involved in formulation of these drugs. The different types of nano-based drug delivery systems used in herbal delivery and their potential to improve therapeutic efficacy are summarized and common techniques for preparing nanocarriers used in herbal drug delivery are also discussed. Finally, a list of nanophytomedicines that have entered clinical trials since 2010, as well as those that have been approved by the FDA, is presented.

AB - Phytomedicine has been used by humans since ancient times to treat a variety of diseases. However, the use of herbal medicines faces great challenges such as poor water and lipid solubility and instability, which lead to low bioavailability and insufficient therapeutic efficacy. Recently, it has been shown that nanotechnology-based drug delivery systems are appropriate to overcome the above-mentioned limitations. The present review first discusses herbal medicines and the challenges involved in formulation of these drugs. The different types of nano-based drug delivery systems used in herbal delivery and their potential to improve therapeutic efficacy are summarized and common techniques for preparing nanocarriers used in herbal drug delivery are also discussed. Finally, a list of nanophytomedicines that have entered clinical trials since 2010, as well as those that have been approved by the FDA, is presented.

KW - Phytomedicine

KW - Herbal drug

KW - Nanotechnology

KW - Drug delivery systems

KW - Nanophytomedicine

U2 - 10.34172/apb.2023.087

DO - 10.34172/apb.2023.087

M3 - Review article

JO - Advanced Pharmaceutical Bulletin

JF - Advanced Pharmaceutical Bulletin

SN - 2228-5881

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