Cysteinyl peptide inhibitors of Bacillus cereus zinc β-lactamase

Sakina Bounaga, Moreno Galleni, Andrew P. Laws, Michael I. Page

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-β-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2001

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