@article{80bdd7539cd146c682ec53ac0980c23f,
title = "Cytotoxicity of Ruthenium(II) Arene Complexes Containing Functionalized Ferrocenyl β-Diketonate Ligands",
abstract = "The synthesis and characterization of 24 ruthenium(II) arene complexes of the type [(p-cym)RuCl(Fc-acac)] (where p-cym = p-cymene and Fc-acac = functionalized ferrocenyl β-diketonate ligands) are reported, including single-crystal X-ray diffraction for 21 new complexes. Chemosensitivity studies have been conducted against human pancreatic carcinoma (MIA PaCa-2), human colorectal adenocarcinoma p53-wildtype (HCT116 p53+/+) and normal human retinal epithelial cell lines (APRE-19). The most active complex, which contains a 2-furan-substituted ligand (4), is 5x more cytotoxic than the analogs 3-furan complex (5) against MIA PaCa-2. Several complexes were screened under hypoxic conditions and at shorter-time incubations, and their ability to damage DNA was determined by the comet assay. Compounds were also screened for their potential to inhibit the growth of both bacterial and fungal strains.",
keywords = "Ruthenium(II), Functionalized Ferrocenyl β‑Diketonate Ligands, Ligand exchange",
author = "Matthew Allison and Pablo Caram{\'e}s-M{\'e}ndez and Hofmann, {Benjamin J.} and Pask, {Christopher M.} and Phillips, {Roger M.} and Lord, {Rianne M.} and McGowan, {Patrick C.}",
note = "Funding Information: We would like to acknowledge the Institute of Cancer Therapeutics, University of Bradford, and the University of Huddersfield for providing access to the Cat II cell culture facilities. We also thank Ms. Tanya Marinko-Covell (University of Leeds) and Mr. Stephen Boyer (London Metropolitan University) for elemental analysis and give a special thank-you to The Community for Antimicrobial Drug Discovery (CO-ADD) at The University of Queensland{\textquoteright}s Institute for Molecular Bioscience for performing the antibacterial and antifungal studies and who are funded by the Wellcome Trust and The University of Queensland. Publisher Copyright: {\textcopyright} 2023 The Authors. Published by American Chemical Society.",
year = "2023",
month = aug,
day = "14",
doi = "10.1021/acs.organomet.2c00553",
language = "English",
volume = "42",
pages = "1869--1881",
journal = "Organometallics",
issn = "0276-7333",
publisher = "American Chemical Society",
number = "15",
}