Cytotoxicity of Some Synthetic Bis(arylidene) Derivatives of Cyclic Ketones towards Cisplatin-Resistant Human Ovarian Carcinoma Cells

Hinal Patel, Begum Mothia, Jaison Patel, Olatunda Fasanya, Kartheek Sooda, Farideh Javid, Peter B. Wyatt

Research output: Contribution to journalArticle

Abstract

Symmetrical α, α'-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g. cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g. 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
Original languageEnglish
JournalMedicinal Chemistry Research
Publication statusAccepted/In press - 4 Mar 2020

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