Abstract
Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
Original language | English |
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Pages (from-to) | 935-941 |
Number of pages | 7 |
Journal | Medicinal Chemistry Research |
Volume | 29 |
Issue number | 6 |
Early online date | 17 Apr 2020 |
DOIs | |
Publication status | Published - 1 Jun 2020 |