Symmetrical α, α'-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g. cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g. 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
|Journal||Medicinal Chemistry Research|
|Publication status||Accepted/In press - 4 Mar 2020|
Patel, H., Mothia, B., Patel, J., Fasanya, O., Sooda, K., Javid, F., & Wyatt, P. B. (Accepted/In press). Cytotoxicity of Some Synthetic Bis(arylidene) Derivatives of Cyclic Ketones towards Cisplatin-Resistant Human Ovarian Carcinoma Cells. Medicinal Chemistry Research.