Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Hinal Patel, Begum Mothia, Jaison Patel, Olatunda Fasanya, Kartheek Sooda, Farideh Javid, Peter B. Wyatt

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

Original languageEnglish
Pages (from-to)935-941
Number of pages7
JournalMedicinal Chemistry Research
Volume29
Issue number6
Early online date17 Apr 2020
DOIs
Publication statusPublished - 1 Jun 2020

Fingerprint

Dive into the research topics of 'Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells'. Together they form a unique fingerprint.

Cite this