Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Hinal Patel; Begum Mothia; Jaison Patel; Olatunda Fasanya; Kartheek Sooda; Farideh Javid; Peter B. Wyatt

doi:10.1007/s00044-020-02532-5

Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Hinal Patel, Begum Mothia, Jaison Patel, Olatunda Fasanya, Kartheek Sooda, Farideh Javid, Peter B. Wyatt

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

Original language	English
Pages (from-to)	935-941
Number of pages	7
Journal	Medicinal Chemistry Research
Volume	29
Issue number	6
Early online date	17 Apr 2020
DOIs	https://doi.org/10.1007/s00044-020-02532-5
Publication status	Published - 1 Jun 2020

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title = "Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells",

abstract = "Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.",

keywords = "ovarian cancer, dienone, cytotoxicity, Curcumin, carboplatin, cisplatin, Drug resistance, Carboplatin, Cytotoxicity, Cisplatin, Dienone, Ovarian cancer",

author = "Hinal Patel and Begum Mothia and Jaison Patel and Olatunda Fasanya and Kartheek Sooda and Farideh Javid and Wyatt, {Peter B.}",

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doi = "10.1007/s00044-020-02532-5",

language = "English",

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TY - JOUR

T1 - Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

AU - Patel, Hinal

AU - Mothia, Begum

AU - Patel, Jaison

AU - Fasanya, Olatunda

AU - Sooda, Kartheek

AU - Javid, Farideh

AU - Wyatt, Peter B.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

AB - Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

KW - ovarian cancer

KW - dienone

KW - cytotoxicity

KW - Curcumin

KW - carboplatin

KW - cisplatin

KW - Drug resistance

KW - Carboplatin

KW - Cytotoxicity

KW - Cisplatin

KW - Dienone

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=85084036373&partnerID=8YFLogxK

U2 - 10.1007/s00044-020-02532-5

DO - 10.1007/s00044-020-02532-5

M3 - Article

VL - 29

SP - 935

EP - 941

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 6

ER -

Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Abstract

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