Dental caries: From infection to prevention

Barira Islam, Shahper N. Khan, Asad U. Khan

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Dental caries is one of the most prevalent diseases in humans, second only to the common cold. It causes irreversible damage to the grinding machinery involved in the intake of food and hence causes great distress. The changes in the homeostasis of the oral cavity with an overgrowth of Streptococcus mutans is recognized as the primary cause of the disease. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence. S. mutans strongly adheres and releases acids by the fermentation of carbohydrates, leading to the demineralization of the tooth. This attachment is mediated mostly by the interaction of surface proteins and bacterial polysaccharides. Ambiguities in the basic treatment of dental caries, such as the use of fluoride and antibiotics, vitalize the deployment of probiotic therapies for its cure. The growing research in herbal treatments has led to the discovery of various phytochemicals to limit the virulence of S. mutans. This review focuses on the properties of S. mutans in cariogenicity and outlines ways to combat dental caries.

Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalMedical Science Monitor
Volume13
Issue number11
Publication statusPublished - 1 Nov 2007
Externally publishedYes

Fingerprint

Streptococcus mutans
Dental Caries
Infection
Virulence
Tooth Demineralization
Bacterial Polysaccharides
Common Cold
Probiotics
Phytochemicals
Fluorides
Fermentation
Mouth
Membrane Proteins
Homeostasis
Eating
Carbohydrates
Anti-Bacterial Agents
Bacteria
Acids
Research

Cite this

Islam, B., Khan, S. N., & Khan, A. U. (2007). Dental caries: From infection to prevention. Medical Science Monitor, 13(11), 196-203.
Islam, Barira ; Khan, Shahper N. ; Khan, Asad U. / Dental caries : From infection to prevention. In: Medical Science Monitor. 2007 ; Vol. 13, No. 11. pp. 196-203.
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Islam, B, Khan, SN & Khan, AU 2007, 'Dental caries: From infection to prevention', Medical Science Monitor, vol. 13, no. 11, pp. 196-203.

Dental caries : From infection to prevention. / Islam, Barira; Khan, Shahper N.; Khan, Asad U.

In: Medical Science Monitor, Vol. 13, No. 11, 01.11.2007, p. 196-203.

Research output: Contribution to journalReview article

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T1 - Dental caries

T2 - From infection to prevention

AU - Islam, Barira

AU - Khan, Shahper N.

AU - Khan, Asad U.

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Islam B, Khan SN, Khan AU. Dental caries: From infection to prevention. Medical Science Monitor. 2007 Nov 1;13(11):196-203.