Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

Ernest B. Cady, Ann Lorek, Juliet Penrice, E. Osmund R. Reynolds, Richard A. Iles, Shamus P. Burns, Glyn A. Coutts, Frances M. Cowan

Research output: Contribution to journalComment/debate

29 Citations (Scopus)

Abstract

Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.
Original languageEnglish
Pages (from-to)764-767
Number of pages4
JournalMagnetic Resonance in Medicine
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 1994
Externally publishedYes

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Cerebrospinal Fluid
Brain
Phenytoin
Phenobarbital
Anticonvulsants
Protons
Spectrum Analysis
Seizures
Newborn Infant
Injections
In Vitro Techniques
Proton Magnetic Resonance Spectroscopy

Cite this

Cady, Ernest B. ; Lorek, Ann ; Penrice, Juliet ; Reynolds, E. Osmund R. ; Iles, Richard A. ; Burns, Shamus P. ; Coutts, Glyn A. ; Cowan, Frances M. / Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. In: Magnetic Resonance in Medicine. 1994 ; Vol. 32, No. 6. pp. 764-767.
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abstract = "Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.",
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Cady, EB, Lorek, A, Penrice, J, Reynolds, EOR, Iles, RA, Burns, SP, Coutts, GA & Cowan, FM 1994, 'Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy', Magnetic Resonance in Medicine, vol. 32, no. 6, pp. 764-767. https://doi.org/10.1002/mrm.1910320611

Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. / Cady, Ernest B.; Lorek, Ann; Penrice, Juliet; Reynolds, E. Osmund R.; Iles, Richard A.; Burns, Shamus P.; Coutts, Glyn A.; Cowan, Frances M.

In: Magnetic Resonance in Medicine, Vol. 32, No. 6, 12.1994, p. 764-767.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

AU - Cady, Ernest B.

AU - Lorek, Ann

AU - Penrice, Juliet

AU - Reynolds, E. Osmund R.

AU - Iles, Richard A.

AU - Burns, Shamus P.

AU - Coutts, Glyn A.

AU - Cowan, Frances M.

PY - 1994/12

Y1 - 1994/12

N2 - Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.

AB - Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.

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KW - NMR spectroscopy

KW - propan‐1,2‐diol

KW - propylene glycol

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U2 - 10.1002/mrm.1910320611

DO - 10.1002/mrm.1910320611

M3 - Comment/debate

VL - 32

SP - 764

EP - 767

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

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