Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

Ernest B. Cady, Ann Lorek, Juliet Penrice, E. Osmund R. Reynolds, Richard A. Iles, Shamus P. Burns, Glyn A. Coutts, Frances M. Cowan

Research output: Contribution to journalComment/debate

30 Citations (Scopus)

Abstract

Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.
Original languageEnglish
Pages (from-to)764-767
Number of pages4
JournalMagnetic Resonance in Medicine
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 1994
Externally publishedYes

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