Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

Ernest B. Cady; Ann Lorek; Juliet Penrice; E. Osmund R. Reynolds; Richard A. Iles; Shamus P. Burns; Glyn A. Coutts; Frances M. Cowan

doi:10.1002/mrm.1910320611

Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

Ernest B. Cady, Ann Lorek, Juliet Penrice, E. Osmund R. Reynolds, Richard A. Iles, Shamus P. Burns, Glyn A. Coutts, Frances M. Cowan

Research output: Contribution to journal › Comment/debate › peer-review

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Abstract

Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.

Original language	English
Pages (from-to)	764-767
Number of pages	4
Journal	Magnetic Resonance in Medicine
Volume	32
Issue number	6
DOIs	https://doi.org/10.1002/mrm.1910320611
Publication status	Published - Dec 1994
Externally published	Yes

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title = "Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy",

abstract = "Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.",

keywords = "brain, NMR spectroscopy, propan‐1,2‐diol, propylene glycol",

author = "Cady, {Ernest B.} and Ann Lorek and Juliet Penrice and Reynolds, {E. Osmund R.} and Iles, {Richard A.} and Burns, {Shamus P.} and Coutts, {Glyn A.} and Cowan, {Frances M.}",

year = "1994",

month = dec,

doi = "10.1002/mrm.1910320611",

language = "English",

volume = "32",

pages = "764--767",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

AU - Cady, Ernest B.

AU - Lorek, Ann

AU - Penrice, Juliet

AU - Reynolds, E. Osmund R.

AU - Iles, Richard A.

AU - Burns, Shamus P.

AU - Coutts, Glyn A.

AU - Cowan, Frances M.

PY - 1994/12

Y1 - 1994/12

N2 - Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.

AB - Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan‐1,2‐diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated in vivo propan‐1,2‐diol concentration (∼3 mM) was less than that measured in the CSF sample (14.4 mM). These observations suggest that propan‐1,2‐diol may accumulate in cerebral tissue and misidentification of its signals in both in vivo and in vitro proton spectra may confuse diagnoses of metabolic or other disorders.

KW - brain

KW - NMR spectroscopy

KW - propan‐1,2‐diol

KW - propylene glycol

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U2 - 10.1002/mrm.1910320611

DO - 10.1002/mrm.1910320611

M3 - Comment/debate

C2 - 7869898

AN - SCOPUS:0028092170

VL - 32

SP - 764

EP - 767

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 6

ER -

Detection of propan‐1,2‐diol in neonatal brain by in vivo proton magnetic resonance spectroscopy

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