Dextran and its potential use as tablet excipient

Luca Casettari, Giulia Bonacucina, Gordon A. Morris, Diego R. Perinelli, Paolo Lucaioli, Marco Cespi, Giovanni Filippo Palmieri

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems. These polysaccharides improve the stability of the therapeutics enabling also the control of their release, via either the parenteral and or oral routes. In the latter case, due to their gel forming ability they may have potential as hydrophilic matrix tablets for sustained drug release.In this paper, we investigated the behaviour of different molecular weight (1, 40, 500 and 2300. kDa) dextrans as tabletting excipients. Powder particle size and hygroscopic studies have been reported, together with tabletability, tablet stability and tablet swelling. Moreover we use tramadol as model compound to evaluate the ability of dextrans to control drug dissolution. The results suggest that dextrans with lower molecular weights may be a promising excipient to be used as filler for immediate release tablets, due to their good tabletability and fast dissolution rate, while dextrans with higher molecular weights could be an efficient disintegrant due to their swelling ability.

LanguageEnglish
Pages125-132
Number of pages8
JournalPowder Technology
Volume273
DOIs
Publication statusPublished - 1 Mar 2015

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Dextran
Excipients
Dextrans
Tablets
Molecular weight
Pharmaceutical Preparations
Swelling
Dissolution
Tramadol
Polysaccharides
Carbohydrates
Powders
Drug products
Fillers
Polymers
Gels
Particle size

Cite this

Casettari, L., Bonacucina, G., Morris, G. A., Perinelli, D. R., Lucaioli, P., Cespi, M., & Palmieri, G. F. (2015). Dextran and its potential use as tablet excipient. Powder Technology, 273, 125-132. https://doi.org/10.1016/j.powtec.2014.12.030
Casettari, Luca ; Bonacucina, Giulia ; Morris, Gordon A. ; Perinelli, Diego R. ; Lucaioli, Paolo ; Cespi, Marco ; Palmieri, Giovanni Filippo. / Dextran and its potential use as tablet excipient. In: Powder Technology. 2015 ; Vol. 273. pp. 125-132.
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Casettari, L, Bonacucina, G, Morris, GA, Perinelli, DR, Lucaioli, P, Cespi, M & Palmieri, GF 2015, 'Dextran and its potential use as tablet excipient', Powder Technology, vol. 273, pp. 125-132. https://doi.org/10.1016/j.powtec.2014.12.030

Dextran and its potential use as tablet excipient. / Casettari, Luca; Bonacucina, Giulia; Morris, Gordon A.; Perinelli, Diego R.; Lucaioli, Paolo; Cespi, Marco; Palmieri, Giovanni Filippo.

In: Powder Technology, Vol. 273, 01.03.2015, p. 125-132.

Research output: Contribution to journalArticle

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Casettari L, Bonacucina G, Morris GA, Perinelli DR, Lucaioli P, Cespi M et al. Dextran and its potential use as tablet excipient. Powder Technology. 2015 Mar 1;273:125-132. https://doi.org/10.1016/j.powtec.2014.12.030