Dietary habits, lifestyle factors and neurodegenerative diseases

Aurel Popa-Wagner, Dinu Dumitrascu, Bogdan Capitanescu, Eugen Petcu, Roxana Surugiu, Wen Hui Fang, Danut Adrian Dumbrava

Research output: Contribution to journalReview articlepeer-review

94 Citations (Scopus)


Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population. Our review is focused on the link between diet, as part of 'modern lifestyle', and health in the context of genetic predisposition of individuals to 'unhealthy' metabolic pathway activity. It is concluded that lifestyle including high sugar diets, alcohol and tobacco addiction or high fat diets as well as ageing, brain injury, oxidative stress and neuroinflammation, negatively influence the onset, severity and duration of neurodegenerative diseases. Fortunately, there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin, resveratrol, blueberry polyphenols, sulphoraphane, salvionic acid as well as caloric restriction and physical activity, which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalNeural Regeneration Research
Issue number3
Early online date26 Sep 2019
Publication statusPublished - 1 Mar 2020
Externally publishedYes


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