Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

Stephen E. Clayton, Christopher D. Gabbutt, John D. Hepworth, B. Mark Heron

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner.

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.
Original languageEnglish
Pages (from-to)939-946
Number of pages8
JournalTetrahedron
Volume49
Issue number4
DOIs
Publication statusPublished - 22 Jan 1993
Externally publishedYes

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