Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

Stephen E. Clayton, Christopher D. Gabbutt, John D. Hepworth, B. Mark Heron

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner.

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.
LanguageEnglish
Pages939-946
Number of pages8
JournalTetrahedron
Volume49
Issue number4
DOIs
Publication statusPublished - 22 Jan 1993
Externally publishedYes

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Acids
Sulfonic Acids
Methane
thiophenol
methanesulfonic acid
beta-butyrolactone

Cite this

Clayton, Stephen E. ; Gabbutt, Christopher D. ; Hepworth, John D. ; Heron, B. Mark. / Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones. In: Tetrahedron. 1993 ; Vol. 49, No. 4. pp. 939-946.
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Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones. / Clayton, Stephen E.; Gabbutt, Christopher D.; Hepworth, John D.; Heron, B. Mark.

In: Tetrahedron, Vol. 49, No. 4, 22.01.1993, p. 939-946.

Research output: Contribution to journalArticle

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