Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

Stephen E. Clayton; Christopher D. Gabbutt; John D. Hepworth; B. Mark Heron

doi:10.1016/S0040-4020(01)80335-5

Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

Stephen E. Clayton, Christopher D. Gabbutt, John D. Hepworth, B. Mark Heron

University of Lancashire

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner.

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.

Original language	English
Pages (from-to)	939-946
Number of pages	8
Journal	Tetrahedron
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/S0040-4020(01)80335-5
Publication status	Published - 22 Jan 1993
Externally published	Yes

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title = "Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones",

abstract = "The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner. The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.",

author = "Clayton, \{Stephen E.\} and Gabbutt, \{Christopher D.\} and Hepworth, \{John D.\} and Heron, \{B. Mark\}",

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T1 - Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

AU - Clayton, Stephen E.

AU - Gabbutt, Christopher D.

AU - Hepworth, John D.

AU - Heron, B. Mark

PY - 1993/1/22

Y1 - 1993/1/22

N2 - The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner. The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.

AB - The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner. The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methanesulphonic acid is accompanied by tert-butylation of the aromatic ring.

UR - https://www.scopus.com/pages/publications/0027509258

U2 - 10.1016/S0040-4020(01)80335-5

DO - 10.1016/S0040-4020(01)80335-5

M3 - Article

AN - SCOPUS:0027509258

SN - 0040-4020

VL - 49

SP - 939

EP - 946

JO - Tetrahedron

JF - Tetrahedron

IS - 4

ER -

Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

Abstract

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