Krankheitsspezifische Hautmodelle

In-vitro-Modelle für die Entwicklung von Therapien bei angeborenen Verhornungsstörungen am Beispiel der kongenitalen Ichthyosen

Translated title of the contribution: Disease-specific skin models: In vitro models for the development of treatment approaches to inherited disorders of cornification as illustrated by congenital ichthyosis

K. M. Eckl, H. C. Hennies

Research output: Contribution to journalReview article

Abstract

A variety of skin equivalent systems have been developed recently mainly for burn therapy but also for studies of the cell and molecular biology of dermatologic and immunologic disorders and for cosmetic and pharmaceutical research. Since European regulation forbids the use of animals to prove product safety in cosmetic products, several commercially available three-dimensional skin models were developed by the cosmetic and chemical industry and validated according to OECD and ECVAM regulations. Three-dimensional skin models consist of two compartments: one serves as a dermal equivalent, usually consisting of fibroblasts in type I collagen, onto which a terminally differentiating epidermis is placed. Up-to-date models are missing that mimic monogenic skin disorders or signs of disease in the skin caused by a systemic autoimmune disorder. We recently developed a three-dimensional skin model for congenital ichthyosis as an example for a keratinization disorder. The system is being validated and will be fundamental for studies of disturbed epidermal differentiation and pharmaceutical intervention.

Original languageGerman
Pages (from-to)487-492
Number of pages6
JournalMedizinische Genetik
Volume21
Issue number4
DOIs
Publication statusPublished - 1 Dec 2009
Externally publishedYes

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Ichthyosis
Skin Diseases
Skin
Cosmetics
Therapeutics
Chemical Industry
Collagen Type I
Epidermis
Cell Biology
In Vitro Techniques
Molecular Biology
Fibroblasts
Safety
Pharmaceutical Preparations

Cite this

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title = "Krankheitsspezifische Hautmodelle: In-vitro-Modelle f{\"u}r die Entwicklung von Therapien bei angeborenen Verhornungsst{\"o}rungen am Beispiel der kongenitalen Ichthyosen",
abstract = "A variety of skin equivalent systems have been developed recently mainly for burn therapy but also for studies of the cell and molecular biology of dermatologic and immunologic disorders and for cosmetic and pharmaceutical research. Since European regulation forbids the use of animals to prove product safety in cosmetic products, several commercially available three-dimensional skin models were developed by the cosmetic and chemical industry and validated according to OECD and ECVAM regulations. Three-dimensional skin models consist of two compartments: one serves as a dermal equivalent, usually consisting of fibroblasts in type I collagen, onto which a terminally differentiating epidermis is placed. Up-to-date models are missing that mimic monogenic skin disorders or signs of disease in the skin caused by a systemic autoimmune disorder. We recently developed a three-dimensional skin model for congenital ichthyosis as an example for a keratinization disorder. The system is being validated and will be fundamental for studies of disturbed epidermal differentiation and pharmaceutical intervention.",
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T2 - In-vitro-Modelle für die Entwicklung von Therapien bei angeborenen Verhornungsstörungen am Beispiel der kongenitalen Ichthyosen

AU - Eckl, K. M.

AU - Hennies, H. C.

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N2 - A variety of skin equivalent systems have been developed recently mainly for burn therapy but also for studies of the cell and molecular biology of dermatologic and immunologic disorders and for cosmetic and pharmaceutical research. Since European regulation forbids the use of animals to prove product safety in cosmetic products, several commercially available three-dimensional skin models were developed by the cosmetic and chemical industry and validated according to OECD and ECVAM regulations. Three-dimensional skin models consist of two compartments: one serves as a dermal equivalent, usually consisting of fibroblasts in type I collagen, onto which a terminally differentiating epidermis is placed. Up-to-date models are missing that mimic monogenic skin disorders or signs of disease in the skin caused by a systemic autoimmune disorder. We recently developed a three-dimensional skin model for congenital ichthyosis as an example for a keratinization disorder. The system is being validated and will be fundamental for studies of disturbed epidermal differentiation and pharmaceutical intervention.

AB - A variety of skin equivalent systems have been developed recently mainly for burn therapy but also for studies of the cell and molecular biology of dermatologic and immunologic disorders and for cosmetic and pharmaceutical research. Since European regulation forbids the use of animals to prove product safety in cosmetic products, several commercially available three-dimensional skin models were developed by the cosmetic and chemical industry and validated according to OECD and ECVAM regulations. Three-dimensional skin models consist of two compartments: one serves as a dermal equivalent, usually consisting of fibroblasts in type I collagen, onto which a terminally differentiating epidermis is placed. Up-to-date models are missing that mimic monogenic skin disorders or signs of disease in the skin caused by a systemic autoimmune disorder. We recently developed a three-dimensional skin model for congenital ichthyosis as an example for a keratinization disorder. The system is being validated and will be fundamental for studies of disturbed epidermal differentiation and pharmaceutical intervention.

KW - Congenital ichthyosis

KW - ECVAM

KW - Nanoparticles

KW - OECD

KW - Skin models

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