Displacing Sedentary Time: Association with Cardiovascular Disease Prevalence

Shaun Wellburn, Cormac G. Ryan, Liane B. Azevedo, Louisa Ells, Denis J. Martin, Greg Atkinson, Alan M. Batterham

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose Isotemporal substitution analysis offers new insights for public health but has only recently been applied to sedentary behavior research. We aimed to quantify associations between the substitution of 10 min of sedentary behavior with 10 min of light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) and the prevalence of cardiovascular disease (CVD). Age was also explored as a potential effect modifier. Methods We completed a secondary analysis of data from 1477 adults from the Health Survey for England (2008). Sedentary time, LPA, and MVPA were measured using accelerometry. We applied isotemporal models to quantify the relationship with CVD prevalence of replacing 10 min of sedentary time with equivalent amounts of LPA or MVPA. Prevalence risk ratios (RR) with 95% confidence intervals (CI) are presented, adjusted for covariates. The role of age as an effect modifier was explored via age-MVPA and age-LPA interactions. CVD was defined as per the International Classification of Diseases. Results The prevalence of CVD was 24%. The RR was 0.97 (95% CI, 0.96-0.99) for LPA and 0.88 (0.81-0.96) for MVPA. Substitution of approximately 50 min of LPA would be required for an association equivalent to 10 min of MVPA. The beneficial association of MVPA was attenuated with age, with a decrease in the relative risk reduction of approximately 7% per decade. Conclusions Isotemporal substitution of sedentary time with LPA was associated with a trivial relative risk reduction for CVD, whereas the equivalent replacement with MVPA had a small beneficial relationship. With respect to CVD prevalence, MVPA might become decreasingly important in older individuals. Prospective studies are needed to investigate causality.

Original languageEnglish
Pages (from-to)641-647
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume48
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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Cardiovascular Diseases
Light
Risk Reduction Behavior
Odds Ratio
Accelerometry
Confidence Intervals
International Classification of Diseases
Health Surveys
Causality
England
Public Health
Prospective Studies
Research

Cite this

Wellburn, Shaun ; Ryan, Cormac G. ; Azevedo, Liane B. ; Ells, Louisa ; Martin, Denis J. ; Atkinson, Greg ; Batterham, Alan M. / Displacing Sedentary Time : Association with Cardiovascular Disease Prevalence . In: Medicine and Science in Sports and Exercise. 2016 ; Vol. 48, No. 4. pp. 641-647.
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abstract = "Purpose Isotemporal substitution analysis offers new insights for public health but has only recently been applied to sedentary behavior research. We aimed to quantify associations between the substitution of 10 min of sedentary behavior with 10 min of light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) and the prevalence of cardiovascular disease (CVD). Age was also explored as a potential effect modifier. Methods We completed a secondary analysis of data from 1477 adults from the Health Survey for England (2008). Sedentary time, LPA, and MVPA were measured using accelerometry. We applied isotemporal models to quantify the relationship with CVD prevalence of replacing 10 min of sedentary time with equivalent amounts of LPA or MVPA. Prevalence risk ratios (RR) with 95{\%} confidence intervals (CI) are presented, adjusted for covariates. The role of age as an effect modifier was explored via age-MVPA and age-LPA interactions. CVD was defined as per the International Classification of Diseases. Results The prevalence of CVD was 24{\%}. The RR was 0.97 (95{\%} CI, 0.96-0.99) for LPA and 0.88 (0.81-0.96) for MVPA. Substitution of approximately 50 min of LPA would be required for an association equivalent to 10 min of MVPA. The beneficial association of MVPA was attenuated with age, with a decrease in the relative risk reduction of approximately 7{\%} per decade. Conclusions Isotemporal substitution of sedentary time with LPA was associated with a trivial relative risk reduction for CVD, whereas the equivalent replacement with MVPA had a small beneficial relationship. With respect to CVD prevalence, MVPA might become decreasingly important in older individuals. Prospective studies are needed to investigate causality.",
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Displacing Sedentary Time : Association with Cardiovascular Disease Prevalence . / Wellburn, Shaun; Ryan, Cormac G.; Azevedo, Liane B.; Ells, Louisa; Martin, Denis J.; Atkinson, Greg; Batterham, Alan M.

In: Medicine and Science in Sports and Exercise, Vol. 48, No. 4, 01.04.2016, p. 641-647.

Research output: Contribution to journalArticle

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T1 - Displacing Sedentary Time

T2 - Association with Cardiovascular Disease Prevalence

AU - Wellburn, Shaun

AU - Ryan, Cormac G.

AU - Azevedo, Liane B.

AU - Ells, Louisa

AU - Martin, Denis J.

AU - Atkinson, Greg

AU - Batterham, Alan M.

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N2 - Purpose Isotemporal substitution analysis offers new insights for public health but has only recently been applied to sedentary behavior research. We aimed to quantify associations between the substitution of 10 min of sedentary behavior with 10 min of light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) and the prevalence of cardiovascular disease (CVD). Age was also explored as a potential effect modifier. Methods We completed a secondary analysis of data from 1477 adults from the Health Survey for England (2008). Sedentary time, LPA, and MVPA were measured using accelerometry. We applied isotemporal models to quantify the relationship with CVD prevalence of replacing 10 min of sedentary time with equivalent amounts of LPA or MVPA. Prevalence risk ratios (RR) with 95% confidence intervals (CI) are presented, adjusted for covariates. The role of age as an effect modifier was explored via age-MVPA and age-LPA interactions. CVD was defined as per the International Classification of Diseases. Results The prevalence of CVD was 24%. The RR was 0.97 (95% CI, 0.96-0.99) for LPA and 0.88 (0.81-0.96) for MVPA. Substitution of approximately 50 min of LPA would be required for an association equivalent to 10 min of MVPA. The beneficial association of MVPA was attenuated with age, with a decrease in the relative risk reduction of approximately 7% per decade. Conclusions Isotemporal substitution of sedentary time with LPA was associated with a trivial relative risk reduction for CVD, whereas the equivalent replacement with MVPA had a small beneficial relationship. With respect to CVD prevalence, MVPA might become decreasingly important in older individuals. Prospective studies are needed to investigate causality.

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