Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus

An evaluation of the effect of systematic agitation and ionic strength

Kofi Asare-Addo, Enes Supuk, Mohammed H. Mahdi, Adeola O. Adebisi, Elijah Nep, Barbara R. Conway, Waseem Kaialy, Hiba Al-Hamidi, Ali Nokhodchi

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5 Citations (Scopus)

Abstract

The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4 M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1 Pa, 150 Pa, and 320 Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5 Pa, 176.2 Pa and 408.3 Pa for the E50LV, E4M and E10M respectively. The lower G′ value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.

Original languageEnglish
Pages (from-to)481-489
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume143
Early online date24 Mar 2016
DOIs
Publication statusPublished - 1 Jul 2016

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tablets
agitation
Ionic strength
Osmolar Concentration
Tablets
drugs
Gels
chemistry
evaluation
Pharmaceutical Preparations
Dissolution
gels
Theophylline
matrices
Water content
dissolving
Water
Excipients
Stiffness
Scanning electron microscopy

Cite this

@article{d54d41f665c34e9b9890d46602c4962a,
title = "Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength",
abstract = "The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4 M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1 Pa, 150 Pa, and 320 Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5 Pa, 176.2 Pa and 408.3 Pa for the E50LV, E4M and E10M respectively. The lower G′ value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.",
keywords = "Agitation sequence, HPMC polymeric matrix tablets triboelectrification, Ionic concentration strength, Rheology, USP III apparatus",
author = "Kofi Asare-Addo and Enes Supuk and Mahdi, {Mohammed H.} and Adebisi, {Adeola O.} and Elijah Nep and Conway, {Barbara R.} and Waseem Kaialy and Hiba Al-Hamidi and Ali Nokhodchi",
year = "2016",
month = "7",
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doi = "10.1016/j.colsurfb.2016.03.066",
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volume = "143",
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TY - JOUR

T1 - Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus

T2 - An evaluation of the effect of systematic agitation and ionic strength

AU - Asare-Addo, Kofi

AU - Supuk, Enes

AU - Mahdi, Mohammed H.

AU - Adebisi, Adeola O.

AU - Nep, Elijah

AU - Conway, Barbara R.

AU - Kaialy, Waseem

AU - Al-Hamidi, Hiba

AU - Nokhodchi, Ali

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4 M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1 Pa, 150 Pa, and 320 Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5 Pa, 176.2 Pa and 408.3 Pa for the E50LV, E4M and E10M respectively. The lower G′ value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.

AB - The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4 M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1 Pa, 150 Pa, and 320 Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5 Pa, 176.2 Pa and 408.3 Pa for the E50LV, E4M and E10M respectively. The lower G′ value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.

KW - Agitation sequence

KW - HPMC polymeric matrix tablets triboelectrification

KW - Ionic concentration strength

KW - Rheology

KW - USP III apparatus

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U2 - 10.1016/j.colsurfb.2016.03.066

DO - 10.1016/j.colsurfb.2016.03.066

M3 - Article

VL - 143

SP - 481

EP - 489

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

ER -