The introduction at CERN of new extremely energetic particle accelerators, such as the high-luminosity large hadron collider (HL-LHC) or the proposed future circular collider (FCC), will increase the energy stored in the circulating particle beams by almost a factor of two (from 360 to 680 MJ) and of more than 20 (up to 8500 MJ), respectively. In this scenario, it is paramount to assess the dynamic thermomechanical response of materials presently used, or being developed for future use, in beam intercepting devices (such as collimators, targets, dumps, absorbers, spoilers, windows, etc.) exposed to potentially destructive events caused by the impact of energetic particle beams. For this reason, a new HiRadMat experiment, named “MultiMat”, was carried out in October 2017, with the goal of assessing the behaviour of samples exposed to high-intensity, high-energy proton pulses, made of a broad range of materials relevant for collimators and beam intercepting devices, thin-film coatings and advanced equipment. This paper describes the experiment and its main results, collected online thanks to an extensive acquisition system and after the irradiation by non-destructive examination, as well as the numerical simulations performed to benchmark experimental data and extend materials constitutive models.