Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity

Craig Sale, Bryan Saunders, Sean Hudson, John A Wise, Roger C Harris, Caroline D Sunderland

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

PURPOSE: We examined the effect of β-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity.

METHODS: Twenty males (age = 25 ± 5 yr, height = 1.79 ± 0.06 m, body mass = 80.0 ± 10.3 kg) were assigned to either a placebo (P) or a β-alanine (BA; 6.4 g·d(-1) for 4 wk) group based on power max, completing four cycling capacity tests at 110% of power max (CCT110%) to determine time to exhaustion (TTE) and total work done. A CCT(110%) was performed twice (habituation and baseline) before supplementation (with maltodextrin [MD]) and twice after supplementation (with MD and with sodium bicarbonate [SB]), using a crossover design with 2 d of rest between trials, creating four study conditions (PMD, PSB, BAMD, and BASB). Blood pH, Lactate, bicarbonate and base excess were determined at baseline, before exercise, immediately after exercise, and 5 min after exercise. Data were analyzed using repeated-measures ANOVA.

RESULTS: TTE was increased in all conditions after supplementation (+1.6% PMD, +6.5% PSB, +12.1% BAMD, and +16.2% BASB). Both BAMD and BASB resulted in significantly improved TTE compared with that before supplementation (P ≤ 0.01). Although further increases in TTE (4.1%) were shown in BASB compared with BAMD, these differences were not significant (P = 0.74). Differences in total work done were similar to those of TTE. Blood bicarbonate concentrations were significantly (P ≤ 0.001) elevated before exercise in PSB and BASB but not in PMD or BAMD. Blood lactate concentrations were significantly elevated after exercise, remaining elevated after 5 min of recovery (P ≤ 0.001) and were highest in PSB and BASB.

CONCLUSIONS: Results show that BA improved high-intensity cycling capacity. However, despite a 6-s (∼4%) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ∼70% probability of a meaningful positive difference.

Original languageEnglish
Pages (from-to)1972-8
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

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Sodium Bicarbonate
Alanine
Bicarbonates
Lactic Acid
Cross-Over Studies
Analysis of Variance
Placebos

Cite this

Sale, Craig ; Saunders, Bryan ; Hudson, Sean ; Wise, John A ; Harris, Roger C ; Sunderland, Caroline D. / Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity. In: Medicine and Science in Sports and Exercise. 2011 ; Vol. 43, No. 10. pp. 1972-8.
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abstract = "PURPOSE: We examined the effect of β-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity.METHODS: Twenty males (age = 25 ± 5 yr, height = 1.79 ± 0.06 m, body mass = 80.0 ± 10.3 kg) were assigned to either a placebo (P) or a β-alanine (BA; 6.4 g·d(-1) for 4 wk) group based on power max, completing four cycling capacity tests at 110{\%} of power max (CCT110{\%}) to determine time to exhaustion (TTE) and total work done. A CCT(110{\%}) was performed twice (habituation and baseline) before supplementation (with maltodextrin [MD]) and twice after supplementation (with MD and with sodium bicarbonate [SB]), using a crossover design with 2 d of rest between trials, creating four study conditions (PMD, PSB, BAMD, and BASB). Blood pH, Lactate, bicarbonate and base excess were determined at baseline, before exercise, immediately after exercise, and 5 min after exercise. Data were analyzed using repeated-measures ANOVA.RESULTS: TTE was increased in all conditions after supplementation (+1.6{\%} PMD, +6.5{\%} PSB, +12.1{\%} BAMD, and +16.2{\%} BASB). Both BAMD and BASB resulted in significantly improved TTE compared with that before supplementation (P ≤ 0.01). Although further increases in TTE (4.1{\%}) were shown in BASB compared with BAMD, these differences were not significant (P = 0.74). Differences in total work done were similar to those of TTE. Blood bicarbonate concentrations were significantly (P ≤ 0.001) elevated before exercise in PSB and BASB but not in PMD or BAMD. Blood lactate concentrations were significantly elevated after exercise, remaining elevated after 5 min of recovery (P ≤ 0.001) and were highest in PSB and BASB.CONCLUSIONS: Results show that BA improved high-intensity cycling capacity. However, despite a 6-s (∼4{\%}) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ∼70{\%} probability of a meaningful positive difference.",
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Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity. / Sale, Craig; Saunders, Bryan; Hudson, Sean; Wise, John A; Harris, Roger C; Sunderland, Caroline D.

In: Medicine and Science in Sports and Exercise, Vol. 43, No. 10, 10.2011, p. 1972-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity

AU - Sale, Craig

AU - Saunders, Bryan

AU - Hudson, Sean

AU - Wise, John A

AU - Harris, Roger C

AU - Sunderland, Caroline D

PY - 2011/10

Y1 - 2011/10

N2 - PURPOSE: We examined the effect of β-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity.METHODS: Twenty males (age = 25 ± 5 yr, height = 1.79 ± 0.06 m, body mass = 80.0 ± 10.3 kg) were assigned to either a placebo (P) or a β-alanine (BA; 6.4 g·d(-1) for 4 wk) group based on power max, completing four cycling capacity tests at 110% of power max (CCT110%) to determine time to exhaustion (TTE) and total work done. A CCT(110%) was performed twice (habituation and baseline) before supplementation (with maltodextrin [MD]) and twice after supplementation (with MD and with sodium bicarbonate [SB]), using a crossover design with 2 d of rest between trials, creating four study conditions (PMD, PSB, BAMD, and BASB). Blood pH, Lactate, bicarbonate and base excess were determined at baseline, before exercise, immediately after exercise, and 5 min after exercise. Data were analyzed using repeated-measures ANOVA.RESULTS: TTE was increased in all conditions after supplementation (+1.6% PMD, +6.5% PSB, +12.1% BAMD, and +16.2% BASB). Both BAMD and BASB resulted in significantly improved TTE compared with that before supplementation (P ≤ 0.01). Although further increases in TTE (4.1%) were shown in BASB compared with BAMD, these differences were not significant (P = 0.74). Differences in total work done were similar to those of TTE. Blood bicarbonate concentrations were significantly (P ≤ 0.001) elevated before exercise in PSB and BASB but not in PMD or BAMD. Blood lactate concentrations were significantly elevated after exercise, remaining elevated after 5 min of recovery (P ≤ 0.001) and were highest in PSB and BASB.CONCLUSIONS: Results show that BA improved high-intensity cycling capacity. However, despite a 6-s (∼4%) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ∼70% probability of a meaningful positive difference.

AB - PURPOSE: We examined the effect of β-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity.METHODS: Twenty males (age = 25 ± 5 yr, height = 1.79 ± 0.06 m, body mass = 80.0 ± 10.3 kg) were assigned to either a placebo (P) or a β-alanine (BA; 6.4 g·d(-1) for 4 wk) group based on power max, completing four cycling capacity tests at 110% of power max (CCT110%) to determine time to exhaustion (TTE) and total work done. A CCT(110%) was performed twice (habituation and baseline) before supplementation (with maltodextrin [MD]) and twice after supplementation (with MD and with sodium bicarbonate [SB]), using a crossover design with 2 d of rest between trials, creating four study conditions (PMD, PSB, BAMD, and BASB). Blood pH, Lactate, bicarbonate and base excess were determined at baseline, before exercise, immediately after exercise, and 5 min after exercise. Data were analyzed using repeated-measures ANOVA.RESULTS: TTE was increased in all conditions after supplementation (+1.6% PMD, +6.5% PSB, +12.1% BAMD, and +16.2% BASB). Both BAMD and BASB resulted in significantly improved TTE compared with that before supplementation (P ≤ 0.01). Although further increases in TTE (4.1%) were shown in BASB compared with BAMD, these differences were not significant (P = 0.74). Differences in total work done were similar to those of TTE. Blood bicarbonate concentrations were significantly (P ≤ 0.001) elevated before exercise in PSB and BASB but not in PMD or BAMD. Blood lactate concentrations were significantly elevated after exercise, remaining elevated after 5 min of recovery (P ≤ 0.001) and were highest in PSB and BASB.CONCLUSIONS: Results show that BA improved high-intensity cycling capacity. However, despite a 6-s (∼4%) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ∼70% probability of a meaningful positive difference.

KW - Adult

KW - Bicycling/psychology

KW - Cross-Over Studies

KW - Dietary Supplements

KW - Exercise Test

KW - Humans

KW - Hydrogen-Ion Concentration/drug effects

KW - Lactic Acid/blood

KW - Male

KW - Physical Endurance/drug effects

KW - Polysaccharides/administration & dosage

KW - Sodium Bicarbonate/administration & dosage

KW - Young Adult

KW - beta-Alanine/administration & dosage

U2 - 10.1249/MSS.0b013e3182188501

DO - 10.1249/MSS.0b013e3182188501

M3 - Article

VL - 43

SP - 1972

EP - 1978

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 10

ER -