The inevitable deterioration of the lubrication conditions in a gearbox in service can change the tribological properties of the meshing teeth. In turn, such changes can significantly affect the dynamic responses and running status of gear systems. This paper investigates such an effect by utilizing virtual prototype technology to model and simulate the dynamics of a wind turbine gearbox system. The change in the lubrication conditions is modeled by the changes in the friction coefficients, thereby indicating that poor lubrication causes not only increased frictional losses but also significant changes in the dynamic responses. These results are further demonstrated by the mean and root mean square values calculated by the simulated responses under different friction coefficients. In addition, the spectrum exhibits significant changes in the first, second, and third harmonics of the meshing components. The findings and simulation method of this study provide theoretical bases for the development of accurate diagnostic techniques.