Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler® dry powder inhaler

Mohamad Abadelah, Firisteh Hazim, Henry Chrystyn, Golshan Bagherisadeghi, Hassan Rahmoune, Hassan Larhrib

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Most patients using dry powder inhalers (DPIs) do not achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of formoterol from an Easyhaler® have been measured using the Andersen Cascade Impactor (ACI) with a maximum inhalation flow (MIF) of 28.3, 60 and 90 L/min and inhaled volumes (Vin) of 240, 750, 1500 and 2000 mL. The total emitted dose (TED) was significantly higher at 90 L/min (p < 0.05), but the difference in the TED between low (28.3 L/min) and high (90 L/min) flow rate was significantly reduced by increasing the Vin. The fine particle dose (FPD) was higher (p < 0.05) at 90 L/min for all Vin values compared to 28.3 and 60 L/min. Similarly the mass median aerodynamic diameter (MMAD) was smaller at 90 L/min across all Vin values. Dose emission characteristics were lower at 240 mL for both MIFs. The results for 240 mL could be due to an insufficient Vin pulled through the ACI or incomplete emptying of the dose metering cup. This study shows that the FPD, %FPF and MMAD were not significantly affected by the vin ≥ 750 mL and that an inhaled volume as low as 750 mL could be used with the ACI.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalEuropean Journal of Pharmaceutical Sciences
Volume104
Early online date27 Mar 2017
DOIs
Publication statusPublished - 15 Jun 2017

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Dry Powder Inhalers
Inhalation
Pharmaceutical Preparations
Formoterol Fumarate
In Vitro Techniques

Cite this

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title = "Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler{\circledR} dry powder inhaler",
abstract = "Most patients using dry powder inhalers (DPIs) do not achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of formoterol from an Easyhaler{\circledR} have been measured using the Andersen Cascade Impactor (ACI) with a maximum inhalation flow (MIF) of 28.3, 60 and 90 L/min and inhaled volumes (Vin) of 240, 750, 1500 and 2000 mL. The total emitted dose (TED) was significantly higher at 90 L/min (p < 0.05), but the difference in the TED between low (28.3 L/min) and high (90 L/min) flow rate was significantly reduced by increasing the Vin. The fine particle dose (FPD) was higher (p < 0.05) at 90 L/min for all Vin values compared to 28.3 and 60 L/min. Similarly the mass median aerodynamic diameter (MMAD) was smaller at 90 L/min across all Vin values. Dose emission characteristics were lower at 240 mL for both MIFs. The results for 240 mL could be due to an insufficient Vin pulled through the ACI or incomplete emptying of the dose metering cup. This study shows that the FPD, {\%}FPF and MMAD were not significantly affected by the vin ≥ 750 mL and that an inhaled volume as low as 750 mL could be used with the ACI.",
keywords = "Andersen Cascade impactor, Easyhaler, Formoterol, Inhaled volume, Maximum inhalation flow",
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Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler® dry powder inhaler. / Abadelah, Mohamad; Hazim, Firisteh; Chrystyn, Henry; Bagherisadeghi, Golshan; Rahmoune, Hassan; Larhrib, Hassan.

In: European Journal of Pharmaceutical Sciences, Vol. 104, 15.06.2017, p. 180-187.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler® dry powder inhaler

AU - Abadelah, Mohamad

AU - Hazim, Firisteh

AU - Chrystyn, Henry

AU - Bagherisadeghi, Golshan

AU - Rahmoune, Hassan

AU - Larhrib, Hassan

PY - 2017/6/15

Y1 - 2017/6/15

N2 - Most patients using dry powder inhalers (DPIs) do not achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of formoterol from an Easyhaler® have been measured using the Andersen Cascade Impactor (ACI) with a maximum inhalation flow (MIF) of 28.3, 60 and 90 L/min and inhaled volumes (Vin) of 240, 750, 1500 and 2000 mL. The total emitted dose (TED) was significantly higher at 90 L/min (p < 0.05), but the difference in the TED between low (28.3 L/min) and high (90 L/min) flow rate was significantly reduced by increasing the Vin. The fine particle dose (FPD) was higher (p < 0.05) at 90 L/min for all Vin values compared to 28.3 and 60 L/min. Similarly the mass median aerodynamic diameter (MMAD) was smaller at 90 L/min across all Vin values. Dose emission characteristics were lower at 240 mL for both MIFs. The results for 240 mL could be due to an insufficient Vin pulled through the ACI or incomplete emptying of the dose metering cup. This study shows that the FPD, %FPF and MMAD were not significantly affected by the vin ≥ 750 mL and that an inhaled volume as low as 750 mL could be used with the ACI.

AB - Most patients using dry powder inhalers (DPIs) do not achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of formoterol from an Easyhaler® have been measured using the Andersen Cascade Impactor (ACI) with a maximum inhalation flow (MIF) of 28.3, 60 and 90 L/min and inhaled volumes (Vin) of 240, 750, 1500 and 2000 mL. The total emitted dose (TED) was significantly higher at 90 L/min (p < 0.05), but the difference in the TED between low (28.3 L/min) and high (90 L/min) flow rate was significantly reduced by increasing the Vin. The fine particle dose (FPD) was higher (p < 0.05) at 90 L/min for all Vin values compared to 28.3 and 60 L/min. Similarly the mass median aerodynamic diameter (MMAD) was smaller at 90 L/min across all Vin values. Dose emission characteristics were lower at 240 mL for both MIFs. The results for 240 mL could be due to an insufficient Vin pulled through the ACI or incomplete emptying of the dose metering cup. This study shows that the FPD, %FPF and MMAD were not significantly affected by the vin ≥ 750 mL and that an inhaled volume as low as 750 mL could be used with the ACI.

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KW - Inhaled volume

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M3 - Article

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JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

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