Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds

Laura Waters, Catherine Finch, A Bhuiyan, Karl Hemming, John Mitchell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.
Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalJournal of Pharmaceutical Analysis
Volume7
Issue number5
Early online date19 May 2017
DOIs
Publication statusPublished - Oct 2017

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