Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds

Laura Waters, Catherine Finch, A Bhuiyan, Karl Hemming, John Mitchell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.
Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalJournal of Pharmaceutical Analysis
Volume7
Issue number5
Early online date19 May 2017
DOIs
Publication statusPublished - Oct 2017

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Permeation
Surface treatment
Plasmas
Pharmaceutical Preparations
Membranes
Skin
Silicones
Caffeine
Permeability
baysilon

Cite this

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title = "Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds",
abstract = "This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.",
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Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds. / Waters, Laura; Finch, Catherine; Bhuiyan, A; Hemming, Karl; Mitchell, John.

In: Journal of Pharmaceutical Analysis, Vol. 7, No. 5, 10.2017, p. 338-342.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds

AU - Waters, Laura

AU - Finch, Catherine

AU - Bhuiyan, A

AU - Hemming, Karl

AU - Mitchell, John

PY - 2017/10

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N2 - This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

AB - This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

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KW - Silicone

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KW - Flux

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