Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow; Dinesh Sanggaran Ramachandram; Syed Shahzad Hasan; Kaeshaelya Thiruchelvam

doi:10.1111/ajd.14466

Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow, Dinesh Sanggaran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam

Research output: Contribution to journal › Review article › peer-review

Abstract

This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

Original language	English
Number of pages	5
Journal	Australasian Journal of Dermatology
Early online date	25 Mar 2025
DOIs	https://doi.org/10.1111/ajd.14466
Publication status	E-pub ahead of print - 25 Mar 2025

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title = "Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials",

abstract = "This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.",

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AU - Hasan, Syed Shahzad

AU - Thiruchelvam, Kaeshaelya

PY - 2025/3/25

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AB - This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

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KW - inflammatory skin disorders

KW - phosphodiesterase-4 inhibitor

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KW - topical application

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ER -

Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Abstract

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