Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow; Dinesh Sanggaran Ramachandram; Syed Shahzad Hasan; Kaeshaelya Thiruchelvam

doi:10.1111/ajd.14466

Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow, Dinesh Sanggaran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Australasian Journal of Dermatology
Volume	66
Issue number	4
Early online date	25 Mar 2025
DOIs	https://doi.org/10.1111/ajd.14466
Publication status	Published - 1 Jun 2025

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title = "Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials",

abstract = "This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.",

keywords = "eczema, inflammatory skin disorders, phosphodiesterase-4 inhibitor, roflumilast, topical application",

author = "Kow, \{Chia Siang\} and Ramachandram, \{Dinesh Sanggaran\} and Hasan, \{Syed Shahzad\} and Kaeshaelya Thiruchelvam",

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T2 - A Systematic Review and Meta-Analysis of Randomised Controlled Trials

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AU - Ramachandram, Dinesh Sanggaran

AU - Hasan, Syed Shahzad

AU - Thiruchelvam, Kaeshaelya

PY - 2025/6/1

Y1 - 2025/6/1

N2 - This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

AB - This systematic review and meta-analysis evaluated the efficacy and safety of roflumilast cream in treating atopic dermatitis (AD) by analysing data from three randomised controlled trials. The results demonstrated significant improvement in treatment success with roflumilast compared to vehicle creams, with a modest increase in mild adverse events, supporting its potential as an effective and well-tolerated treatment for AD.

KW - eczema

KW - inflammatory skin disorders

KW - phosphodiesterase-4 inhibitor

KW - roflumilast

KW - topical application

UR - https://www.scopus.com/pages/publications/105000719767

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DO - 10.1111/ajd.14466

M3 - Review article

AN - SCOPUS:105000719767

SN - 0004-8380

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SP - 220

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JO - Australasian Journal of Dermatology

JF - Australasian Journal of Dermatology

IS - 4

ER -

Efficacy and Safety of Roflumilast Cream in Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

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