Electrophoretic motion of particles in a microsystem

Y. F. Yap, J. C. Chai, T. N. Wong, N. T. Nguyen, K. C. Toh, H. Y. Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrophoresis is the motion of a charged particle relative to the surrounding liquid due to an imposed external electric field1. Its applications include but are not limited to characterization and manipulation of organic and inorganic particles. In particular, electrophoresis has been applied to a variety of analytical separation problems involving nucleic acids, proteins and drugs. For electrophoresis on various Lab-on-a-chip platforms, the particles are of sizes comparable to the microchannel in which they flow. As such, particle-particle and particle-wall interactions are no longer negligible. Therefore, the electric field, the flow field and the particles motion are strongly coupled together. Numerical models based on a moving-grid method 2 have been employed to investigate the related phenomena. Mesh regeneration as the particles move is an extra computational complication. To circumvent the complexity of mesh regeneration, a level-set based fixed-grid method3 is presented for electrophoretic motion of particles in this article. The particles are assumed to be a highly viscous liquid constraint to move with rigid body motion. A distance function is employed to represent the liquid-particle interfaces. The electric field, the flow field and the particles motion are governed respectively by the Poisson, the Navier-Stokes and the Euler-Newton equations. The effect of the electric field on the particle motion is accounted for by incorporating slip boundary conditions on the particles surfaces. The nonlinear governing equations are discretized and solved using a finite volume method . The model is used to investigate electrophoretic motion of non-conducting circular and elliptical particles in a microsystem. Figure 1 shows the electrophoretic motion of a single circular particle in a microchannel. The induced electroosmotic flow is from the left to the right. The thick circles are the particle at t = 0. The direction of the particle movement is indicated by the arrows. The motions of the particle if neutral, positively or negatively charged are obviously different. Basically, a positively charged particle move faster than the main flow. However, a negatively charged particle flows slower. When the particle is highly charged negative, it can even flow against the streamwise direction toward upstream (+V) as in Fig. 1c. This suggests that therewould be a situation where the particle can be kept static. Figure 2 shows the electrophoretic motion of multiple particles. The initial locations of the particles are shown in Fig. 2a. In the case of charged particles, particle 1, 2 and 3 are respectively negatively, neutral and positively charged. Particle 1 which is elliptical undergoes obvious rotational motion when charged (Fig. 2c). The case of the neutral particles (Fig. 2b) is included for comparison.

Original languageEnglish
Title of host publicationProceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer
PublisherAmerican Society of Mechanical Engineers(ASME)
ISBN (Print)0791837904, 9780791837900
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event2006 ASME International Mechanical Engineering Congress and Exposition - Chicago, United States
Duration: 5 Nov 200610 Nov 2006

Conference

Conference2006 ASME International Mechanical Engineering Congress and Exposition
Abbreviated titleIMECE 2006
CountryUnited States
CityChicago
Period5/11/0610/11/06

Fingerprint

Microsystems
Charged particles
Electrophoresis
Electric fields
Microchannels
Flow fields
Liquids
Lab-on-a-chip
Nucleic acids
Finite volume method
Nonlinear equations
Nucleic Acids
Numerical models
Boundary conditions
Proteins
Pharmaceutical Preparations
Direction compound

Cite this

Yap, Y. F., Chai, J. C., Wong, T. N., Nguyen, N. T., Toh, K. C., & Zheng, H. Y. (2006). Electrophoretic motion of particles in a microsystem. In Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer American Society of Mechanical Engineers(ASME). https://doi.org/10.1115/IMECE2006-14121
Yap, Y. F. ; Chai, J. C. ; Wong, T. N. ; Nguyen, N. T. ; Toh, K. C. ; Zheng, H. Y. / Electrophoretic motion of particles in a microsystem. Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer. American Society of Mechanical Engineers(ASME), 2006.
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abstract = "Electrophoresis is the motion of a charged particle relative to the surrounding liquid due to an imposed external electric field1. Its applications include but are not limited to characterization and manipulation of organic and inorganic particles. In particular, electrophoresis has been applied to a variety of analytical separation problems involving nucleic acids, proteins and drugs. For electrophoresis on various Lab-on-a-chip platforms, the particles are of sizes comparable to the microchannel in which they flow. As such, particle-particle and particle-wall interactions are no longer negligible. Therefore, the electric field, the flow field and the particles motion are strongly coupled together. Numerical models based on a moving-grid method 2 have been employed to investigate the related phenomena. Mesh regeneration as the particles move is an extra computational complication. To circumvent the complexity of mesh regeneration, a level-set based fixed-grid method3 is presented for electrophoretic motion of particles in this article. The particles are assumed to be a highly viscous liquid constraint to move with rigid body motion. A distance function is employed to represent the liquid-particle interfaces. The electric field, the flow field and the particles motion are governed respectively by the Poisson, the Navier-Stokes and the Euler-Newton equations. The effect of the electric field on the particle motion is accounted for by incorporating slip boundary conditions on the particles surfaces. The nonlinear governing equations are discretized and solved using a finite volume method . The model is used to investigate electrophoretic motion of non-conducting circular and elliptical particles in a microsystem. Figure 1 shows the electrophoretic motion of a single circular particle in a microchannel. The induced electroosmotic flow is from the left to the right. The thick circles are the particle at t = 0. The direction of the particle movement is indicated by the arrows. The motions of the particle if neutral, positively or negatively charged are obviously different. Basically, a positively charged particle move faster than the main flow. However, a negatively charged particle flows slower. When the particle is highly charged negative, it can even flow against the streamwise direction toward upstream (+V) as in Fig. 1c. This suggests that therewould be a situation where the particle can be kept static. Figure 2 shows the electrophoretic motion of multiple particles. The initial locations of the particles are shown in Fig. 2a. In the case of charged particles, particle 1, 2 and 3 are respectively negatively, neutral and positively charged. Particle 1 which is elliptical undergoes obvious rotational motion when charged (Fig. 2c). The case of the neutral particles (Fig. 2b) is included for comparison.",
author = "Yap, {Y. F.} and Chai, {J. C.} and Wong, {T. N.} and Nguyen, {N. T.} and Toh, {K. C.} and Zheng, {H. Y.}",
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Yap, YF, Chai, JC, Wong, TN, Nguyen, NT, Toh, KC & Zheng, HY 2006, Electrophoretic motion of particles in a microsystem. in Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer. American Society of Mechanical Engineers(ASME), 2006 ASME International Mechanical Engineering Congress and Exposition, Chicago, United States, 5/11/06. https://doi.org/10.1115/IMECE2006-14121

Electrophoretic motion of particles in a microsystem. / Yap, Y. F.; Chai, J. C.; Wong, T. N.; Nguyen, N. T.; Toh, K. C.; Zheng, H. Y.

Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer. American Society of Mechanical Engineers(ASME), 2006.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Zheng, H. Y.

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N2 - Electrophoresis is the motion of a charged particle relative to the surrounding liquid due to an imposed external electric field1. Its applications include but are not limited to characterization and manipulation of organic and inorganic particles. In particular, electrophoresis has been applied to a variety of analytical separation problems involving nucleic acids, proteins and drugs. For electrophoresis on various Lab-on-a-chip platforms, the particles are of sizes comparable to the microchannel in which they flow. As such, particle-particle and particle-wall interactions are no longer negligible. Therefore, the electric field, the flow field and the particles motion are strongly coupled together. Numerical models based on a moving-grid method 2 have been employed to investigate the related phenomena. Mesh regeneration as the particles move is an extra computational complication. To circumvent the complexity of mesh regeneration, a level-set based fixed-grid method3 is presented for electrophoretic motion of particles in this article. The particles are assumed to be a highly viscous liquid constraint to move with rigid body motion. A distance function is employed to represent the liquid-particle interfaces. The electric field, the flow field and the particles motion are governed respectively by the Poisson, the Navier-Stokes and the Euler-Newton equations. The effect of the electric field on the particle motion is accounted for by incorporating slip boundary conditions on the particles surfaces. The nonlinear governing equations are discretized and solved using a finite volume method . The model is used to investigate electrophoretic motion of non-conducting circular and elliptical particles in a microsystem. Figure 1 shows the electrophoretic motion of a single circular particle in a microchannel. The induced electroosmotic flow is from the left to the right. The thick circles are the particle at t = 0. The direction of the particle movement is indicated by the arrows. The motions of the particle if neutral, positively or negatively charged are obviously different. Basically, a positively charged particle move faster than the main flow. However, a negatively charged particle flows slower. When the particle is highly charged negative, it can even flow against the streamwise direction toward upstream (+V) as in Fig. 1c. This suggests that therewould be a situation where the particle can be kept static. Figure 2 shows the electrophoretic motion of multiple particles. The initial locations of the particles are shown in Fig. 2a. In the case of charged particles, particle 1, 2 and 3 are respectively negatively, neutral and positively charged. Particle 1 which is elliptical undergoes obvious rotational motion when charged (Fig. 2c). The case of the neutral particles (Fig. 2b) is included for comparison.

AB - Electrophoresis is the motion of a charged particle relative to the surrounding liquid due to an imposed external electric field1. Its applications include but are not limited to characterization and manipulation of organic and inorganic particles. In particular, electrophoresis has been applied to a variety of analytical separation problems involving nucleic acids, proteins and drugs. For electrophoresis on various Lab-on-a-chip platforms, the particles are of sizes comparable to the microchannel in which they flow. As such, particle-particle and particle-wall interactions are no longer negligible. Therefore, the electric field, the flow field and the particles motion are strongly coupled together. Numerical models based on a moving-grid method 2 have been employed to investigate the related phenomena. Mesh regeneration as the particles move is an extra computational complication. To circumvent the complexity of mesh regeneration, a level-set based fixed-grid method3 is presented for electrophoretic motion of particles in this article. The particles are assumed to be a highly viscous liquid constraint to move with rigid body motion. A distance function is employed to represent the liquid-particle interfaces. The electric field, the flow field and the particles motion are governed respectively by the Poisson, the Navier-Stokes and the Euler-Newton equations. The effect of the electric field on the particle motion is accounted for by incorporating slip boundary conditions on the particles surfaces. The nonlinear governing equations are discretized and solved using a finite volume method . The model is used to investigate electrophoretic motion of non-conducting circular and elliptical particles in a microsystem. Figure 1 shows the electrophoretic motion of a single circular particle in a microchannel. The induced electroosmotic flow is from the left to the right. The thick circles are the particle at t = 0. The direction of the particle movement is indicated by the arrows. The motions of the particle if neutral, positively or negatively charged are obviously different. Basically, a positively charged particle move faster than the main flow. However, a negatively charged particle flows slower. When the particle is highly charged negative, it can even flow against the streamwise direction toward upstream (+V) as in Fig. 1c. This suggests that therewould be a situation where the particle can be kept static. Figure 2 shows the electrophoretic motion of multiple particles. The initial locations of the particles are shown in Fig. 2a. In the case of charged particles, particle 1, 2 and 3 are respectively negatively, neutral and positively charged. Particle 1 which is elliptical undergoes obvious rotational motion when charged (Fig. 2c). The case of the neutral particles (Fig. 2b) is included for comparison.

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SN - 0791837904

SN - 9780791837900

BT - Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer

PB - American Society of Mechanical Engineers(ASME)

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Yap YF, Chai JC, Wong TN, Nguyen NT, Toh KC, Zheng HY. Electrophoretic motion of particles in a microsystem. In Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer. American Society of Mechanical Engineers(ASME). 2006 https://doi.org/10.1115/IMECE2006-14121