Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

Pushpak Mizar, Aragorn Laverny, Mohamed Elsherbini, Umar Farid, Michael Brown, Florence Malmedy, Thomas Wirth

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.
Original languageEnglish
Pages (from-to)9910-9913
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number32
Early online date17 Jul 2014
DOIs
Publication statusPublished - 4 Aug 2014
Externally publishedYes

Fingerprint

Diamines
Iodine
Drug products
Catalysts
Molecules
Pharmaceutical Preparations
Organic Chemistry

Cite this

Mizar, Pushpak ; Laverny, Aragorn ; Elsherbini, Mohamed ; Farid, Umar ; Brown, Michael ; Malmedy, Florence ; Wirth, Thomas. / Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts. In: Chemistry - A European Journal. 2014 ; Vol. 20, No. 32. pp. 9910-9913.
@article{ab14ea1f126245de89795df567637952,
title = "Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts",
abstract = "Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.",
keywords = "Cyclization, Diamination, Hypervalent iodine, Organocatalysis, Stereoselective synthesis",
author = "Pushpak Mizar and Aragorn Laverny and Mohamed Elsherbini and Umar Farid and Michael Brown and Florence Malmedy and Thomas Wirth",
year = "2014",
month = "8",
day = "4",
doi = "10.1002/chem.201403891",
language = "English",
volume = "20",
pages = "9910--9913",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "32",

}

Mizar, P, Laverny, A, Elsherbini, M, Farid, U, Brown, M, Malmedy, F & Wirth, T 2014, 'Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts', Chemistry - A European Journal, vol. 20, no. 32, pp. 9910-9913. https://doi.org/10.1002/chem.201403891

Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts. / Mizar, Pushpak; Laverny, Aragorn; Elsherbini, Mohamed; Farid, Umar; Brown, Michael; Malmedy, Florence; Wirth, Thomas.

In: Chemistry - A European Journal, Vol. 20, No. 32, 04.08.2014, p. 9910-9913.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

AU - Mizar, Pushpak

AU - Laverny, Aragorn

AU - Elsherbini, Mohamed

AU - Farid, Umar

AU - Brown, Michael

AU - Malmedy, Florence

AU - Wirth, Thomas

PY - 2014/8/4

Y1 - 2014/8/4

N2 - Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.

AB - Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.

KW - Cyclization

KW - Diamination

KW - Hypervalent iodine

KW - Organocatalysis

KW - Stereoselective synthesis

UR - https://www2.scopus.com/record/display.uri?eid=2-s2.0-84905175911&origin=resultslist&sort=plf-f&src=s&st1=Enantioselective+Diamination+with+Novel+Chiral+Hypervalent+Iodine+Catalysts&st2=&sid=d54e80eb3ad628bfa3ac76c209e49505&sot=b&sdt=b&sl=90&s=TITLE-ABS-KEY%28Enantioselective+Diamination+with+Novel+Chiral+Hypervalent+Iodine+Catalysts%29&relpos=0&citeCnt=68&searchTerm=

U2 - 10.1002/chem.201403891

DO - 10.1002/chem.201403891

M3 - Article

VL - 20

SP - 9910

EP - 9913

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 32

ER -