Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

Pushpak Mizar; Aragorn Laverny; Mohamed Elsherbini; Umar Farid; Michael Brown; Florence Malmedy; Thomas Wirth

doi:10.1002/chem.201403891

Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

Pushpak Mizar, Aragorn Laverny, Mohamed Elsherbini, Umar Farid, Michael Brown, Florence Malmedy, Thomas Wirth

Cardiff University

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

Abstract

Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.

Original language	English
Pages (from-to)	9910-9913
Number of pages	4
Journal	Chemistry - A European Journal
Volume	20
Issue number	32
Early online date	17 Jul 2014
DOIs	https://doi.org/10.1002/chem.201403891
Publication status	Published - 4 Aug 2014
Externally published	Yes

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AU - Elsherbini, Mohamed

AU - Farid, Umar

AU - Brown, Michael

AU - Malmedy, Florence

AU - Wirth, Thomas

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AB - Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal‐free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.

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KW - Diamination

KW - Hypervalent iodine

KW - Organocatalysis

KW - Stereoselective synthesis

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Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

Abstract

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