Encapsulation of bacteriophage cocktail into chitosan for the treatment of bacterial diarrhea

Golnar Rahimzadeh, Majid Saeedi, Mahmood Moosazadeh, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Mohammad Sadegh Rezai, Kosar Kamel, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The therapeutic effectiveness of a chitosan encapsulated bacteriophage cocktail as a smart biocontrol agent was evaluated in this study to be used as a preventative and treatment option for gastrointestinal infections. To evaluate the effect of the bacteriophage formulation on the treatment of gastrointestinal infection, rats were infected with Salmonella enterica, Shigella flexneri, and Escherichia coli. The rats were weighed and their stools cultured. The results showed that the group which had the chitosan encapsulated bacteriophage cocktail did not lose weight after 3 days and had significantly lower group weight changes. Weight loss was significant in the rats that had cefixime administered instead. Positive cultured stools were reduced after 4 days compared to 2 days in the treated group with the chitosan encapsulated bacteriophage cocktail. The chitosan encapsulated bacteriophage cocktail can therefore be effective in the treatment of gastrointestinal infections.
Original languageEnglish
Article number15603
Number of pages10
JournalScientific Reports
Issue number1
Publication statusPublished - 2 Aug 2021


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