Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro; Roger M. Phillips; Benjamin D. Crossley; Jake Fielden; Charlotte E. Willans

doi:10.1039/c2dt12399a

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro, Roger M. Phillips, Benjamin D. Crossley, Jake Fielden, Charlotte E. Willans

Research output: Contribution to journal › Article

61 Citations (Scopus)

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Original language	English
Pages (from-to)	3720-3725
Number of pages	6
Journal	Dalton Transactions
Volume	41
Issue number	13
Early online date	6 Jan 2012
DOIs	https://doi.org/10.1039/c2dt12399a
Publication status	Published - 7 Apr 2012
Externally published	Yes

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title = "Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands",

abstract = "A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.",

author = "Monteiro, {Diana C F} and Phillips, {Roger M.} and Crossley, {Benjamin D.} and Jake Fielden and Willans, {Charlotte E.}",

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AU - Phillips, Roger M.

AU - Crossley, Benjamin D.

AU - Fielden, Jake

AU - Willans, Charlotte E.

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N2 - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

AB - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

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