Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro, Roger M. Phillips, Benjamin D. Crossley, Jake Fielden, Charlotte E. Willans

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

LanguageEnglish
Pages3720-3725
Number of pages6
JournalDalton Transactions
Volume41
Issue number13
Early online date6 Jan 2012
DOIs
Publication statusPublished - 7 Apr 2012
Externally publishedYes

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Bearings (structural)
Cytotoxicity
Silver
Ligands
Cisplatin
carbene

Cite this

Monteiro, Diana C F ; Phillips, Roger M. ; Crossley, Benjamin D. ; Fielden, Jake ; Willans, Charlotte E. / Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands. In: Dalton Transactions. 2012 ; Vol. 41, No. 13. pp. 3720-3725.
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Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands. / Monteiro, Diana C F; Phillips, Roger M.; Crossley, Benjamin D.; Fielden, Jake; Willans, Charlotte E.

In: Dalton Transactions, Vol. 41, No. 13, 07.04.2012, p. 3720-3725.

Research output: Contribution to journalArticle

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