Abstract
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
| Original language | English |
|---|---|
| Pages (from-to) | 3720-3725 |
| Number of pages | 6 |
| Journal | Dalton Transactions |
| Volume | 41 |
| Issue number | 13 |
| Early online date | 6 Jan 2012 |
| DOIs | |
| Publication status | Published - 7 Apr 2012 |
| Externally published | Yes |
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Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands. / Monteiro, Diana C F; Phillips, Roger M.; Crossley, Benjamin D.; Fielden, Jake; Willans, Charlotte E.
In: Dalton Transactions, Vol. 41, No. 13, 07.04.2012, p. 3720-3725.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands
AU - Monteiro, Diana C F
AU - Phillips, Roger M.
AU - Crossley, Benjamin D.
AU - Fielden, Jake
AU - Willans, Charlotte E.
PY - 2012/4/7
Y1 - 2012/4/7
N2 - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
AB - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
UR - http://www.scopus.com/inward/record.url?scp=84858429441&partnerID=8YFLogxK
UR - http://pubs.rsc.org/en/journals/journalissues/dt#!recentarticles&adv
U2 - 10.1039/c2dt12399a
DO - 10.1039/c2dt12399a
M3 - Article
VL - 41
SP - 3720
EP - 3725
JO - Dalton Transactions
JF - Dalton Transactions
SN - 1477-9226
IS - 13
ER -