Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro, Roger M. Phillips, Benjamin D. Crossley, Jake Fielden, Charlotte E. Willans

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Original languageEnglish
Pages (from-to)3720-3725
Number of pages6
JournalDalton Transactions
Volume41
Issue number13
Early online date6 Jan 2012
DOIs
Publication statusPublished - 7 Apr 2012
Externally publishedYes

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