Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro; Roger M. Phillips; Benjamin D. Crossley; Jake Fielden; Charlotte E. Willans

doi:10.1039/c2dt12399a

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Diana C F Monteiro, Roger M. Phillips, Benjamin D. Crossley, Jake Fielden, Charlotte E. Willans

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Original language	English
Pages (from-to)	3720-3725
Number of pages	6
Journal	Dalton Transactions
Volume	41
Issue number	13
Early online date	6 Jan 2012
DOIs	https://doi.org/10.1039/c2dt12399a
Publication status	Published - 7 Apr 2012
Externally published	Yes

Access to Document

10.1039/c2dt12399aLicence: Unspecified

Cite this

@article{5843a016ce00476e807586dd105a1782,

title = "Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands",

abstract = "A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.",

author = "Monteiro, {Diana C F} and Phillips, {Roger M.} and Crossley, {Benjamin D.} and Jake Fielden and Willans, {Charlotte E.}",

year = "2012",

month = apr,

day = "7",

doi = "10.1039/c2dt12399a",

language = "English",

volume = "41",

pages = "3720--3725",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "13",

}

TY - JOUR

T1 - Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

AU - Monteiro, Diana C F

AU - Phillips, Roger M.

AU - Crossley, Benjamin D.

AU - Fielden, Jake

AU - Willans, Charlotte E.

PY - 2012/4/7

Y1 - 2012/4/7

N2 - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

AB - A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

UR - http://www.scopus.com/inward/record.url?scp=84858429441&partnerID=8YFLogxK

UR - http://pubs.rsc.org/en/journals/journalissues/dt#!recentarticles&adv

U2 - 10.1039/c2dt12399a

DO - 10.1039/c2dt12399a

M3 - Article

C2 - 22327273

AN - SCOPUS:84858429441

VL - 41

SP - 3720

EP - 3725

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 13

ER -

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Abstract

Access to Document

Other files and links

Fingerprint

Cite this