In recent few years, the widespread applications of indoor navigation have compelled the research community to propose novel solutions for detecting objects position in the Indoor environment. Various approaches have been proposed and implemented concerning the indoor positioning systems. This study propose an fuzzy inference based Kalman filter to improve the position estimation in indoor navigation. The presented system is based on FIS based Kalman filter aiming at predicting the actual sensor readings from the available noisy sensor measurements. The proposed approach has two main components, i.e., multi sensor fusion algorithm for positioning estimation and FIS based Kalman filter algorithm. The position estimation module is used to determine the object location in an indoor environment in an accurate way. Similarly, the FIS based Kalman filter is used to control and tune the Kalman filter by considering the previous output as a feedback. The Kalman filter predicts the actual sensor readings from the available noisy readings. To evaluate the proposed approach, the next-generation inertial measurement unit is used to acquire a three-axis gyroscope and accelerometer sensory data. Lastly, the proposed approach's performance has been investigated considering the MAD, RMSE, and MSE metrics. The obtained results illustrate that the FIS based Kalman filter improve the prediction accuracy against the traditional Kalman filter approach.