Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis

Stephen Buckwell, Michael I. Page, Jethro L. Longridge

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The normal product of hydrolysis of cephalosporins with a leaving group at C-3′ is an α,β-unsaturated imine which is demonstrated to be in equilibrium with its precursor, an enamine; the equilibrium constants for this process are reported for thiolate anions which generate a Bronsted βlg of 0.71.

Original languageEnglish
Pages (from-to)1039-1040
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number13
DOIs
Publication statusPublished - 1 Jul 1986

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Imines
Equilibrium constants
Cephalosporins
Anions
Hydrolysis
Negative ions

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Buckwell, Stephen ; Page, Michael I. ; Longridge, Jethro L. / Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis. In: Journal of the Chemical Society, Chemical Communications. 1986 ; No. 13. pp. 1039-1040.
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Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis. / Buckwell, Stephen; Page, Michael I.; Longridge, Jethro L.

In: Journal of the Chemical Society, Chemical Communications, No. 13, 01.07.1986, p. 1039-1040.

Research output: Contribution to journalArticle

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