Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis

Stephen Buckwell, Michael I. Page, Jethro L. Longridge

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The normal product of hydrolysis of cephalosporins with a leaving group at C-3′ is an α,β-unsaturated imine which is demonstrated to be in equilibrium with its precursor, an enamine; the equilibrium constants for this process are reported for thiolate anions which generate a Bronsted βlg of 0.71.

Original languageEnglish
Pages (from-to)1039-1040
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number13
DOIs
Publication statusPublished - 1 Jul 1986

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