Esterase catalysed enantioselective ring closure

C. Vivienne Barker, Stewart R. Korn, Michael Monteith, Michael I. Page

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Porcine liver esterase catalyses the reaction of γ-amino esters in water to give a mixture of the corresponding γ-lactam and the hydrolysis product, deacylation of the acyl enzyme intermediate by ring closure occurs with a high enantioselectivity giving an ee of 90% for the formation of (S)-5-phenyl-2-pyrrolidone from racemic ethyl 4-phenyl-4-aminobutanoate.

Original languageEnglish
Pages (from-to)721-722
Number of pages2
JournalChemical Communications
Issue number8
Publication statusPublished - 21 Apr 1999


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