Esterase catalysed enantioselective ring closure

C. Vivienne Barker, Stewart R. Korn, Michael Monteith, Michael I. Page

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Porcine liver esterase catalyses the reaction of γ-amino esters in water to give a mixture of the corresponding γ-lactam and the hydrolysis product, deacylation of the acyl enzyme intermediate by ring closure occurs with a high enantioselectivity giving an ee of 90% for the formation of (S)-5-phenyl-2-pyrrolidone from racemic ethyl 4-phenyl-4-aminobutanoate.

LanguageEnglish
Pages721-722
Number of pages2
JournalChemical Communications
Issue number8
DOIs
Publication statusPublished - 21 Apr 1999

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Lactams
Enantioselectivity
Esterases
Liver
Hydrolysis
Esters
Enzymes
Water
2-pyrrolidone

Cite this

Barker, C. V., Korn, S. R., Monteith, M., & Page, M. I. (1999). Esterase catalysed enantioselective ring closure. Chemical Communications, (8), 721-722. https://doi.org/10.1039/A901204D
Barker, C. Vivienne ; Korn, Stewart R. ; Monteith, Michael ; Page, Michael I. / Esterase catalysed enantioselective ring closure. In: Chemical Communications. 1999 ; No. 8. pp. 721-722.
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Barker, CV, Korn, SR, Monteith, M & Page, MI 1999, 'Esterase catalysed enantioselective ring closure', Chemical Communications, no. 8, pp. 721-722. https://doi.org/10.1039/A901204D

Esterase catalysed enantioselective ring closure. / Barker, C. Vivienne; Korn, Stewart R.; Monteith, Michael; Page, Michael I.

In: Chemical Communications, No. 8, 21.04.1999, p. 721-722.

Research output: Contribution to journalArticle

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AU - Korn, Stewart R.

AU - Monteith, Michael

AU - Page, Michael I.

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Barker CV, Korn SR, Monteith M, Page MI. Esterase catalysed enantioselective ring closure. Chemical Communications. 1999 Apr 21;(8):721-722. https://doi.org/10.1039/A901204D