Eukaryotic flagella: Variations in form, function, and composition during evolution

Jonathan Moran, Paul G. McKean, Michael L. Ginger

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture-the classic microtubule configuration seen in most axonemes-belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.

LanguageEnglish
Pages1103-1114
Number of pages12
JournalBioScience
Volume64
Issue number12
Early online date25 Nov 2014
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Fingerprint

Flagella
flagellum
Axoneme
Microtubules
Organelles
microtubules
organelles
eukaryotic cells
protein secretion
Cilia
Eukaryotic Cells
cilia
Prednisolone
Eukaryota
cell biology
Cell Movement
Cell Biology
ancestry
Proteins
protein content

Cite this

Moran, Jonathan ; McKean, Paul G. ; Ginger, Michael L. / Eukaryotic flagella : Variations in form, function, and composition during evolution. In: BioScience. 2014 ; Vol. 64, No. 12. pp. 1103-1114.
@article{661d3a0464874df2b9b90d16f630d9dc,
title = "Eukaryotic flagella: Variations in form, function, and composition during evolution",
abstract = "The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture-the classic microtubule configuration seen in most axonemes-belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.",
keywords = "Cell biology, Centriole, Chlamydomonas, Microtubules, Trypanosoma",
author = "Jonathan Moran and McKean, {Paul G.} and Ginger, {Michael L.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1093/biosci/biu175",
language = "English",
volume = "64",
pages = "1103--1114",
journal = "BioScience",
issn = "0006-3568",
publisher = "American Institute of Biological Sciences",
number = "12",

}

Eukaryotic flagella : Variations in form, function, and composition during evolution. / Moran, Jonathan; McKean, Paul G.; Ginger, Michael L.

In: BioScience, Vol. 64, No. 12, 01.12.2014, p. 1103-1114.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Eukaryotic flagella

T2 - BioScience

AU - Moran, Jonathan

AU - McKean, Paul G.

AU - Ginger, Michael L.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture-the classic microtubule configuration seen in most axonemes-belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.

AB - The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture-the classic microtubule configuration seen in most axonemes-belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.

KW - Cell biology

KW - Centriole

KW - Chlamydomonas

KW - Microtubules

KW - Trypanosoma

UR - http://www.scopus.com/inward/record.url?scp=84922450746&partnerID=8YFLogxK

U2 - 10.1093/biosci/biu175

DO - 10.1093/biosci/biu175

M3 - Article

VL - 64

SP - 1103

EP - 1114

JO - BioScience

JF - BioScience

SN - 0006-3568

IS - 12

ER -