Eukaryotic flagella: Variations in form, function, and composition during evolution

Jonathan Moran, Paul G. McKean, Michael L. Ginger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture-the classic microtubule configuration seen in most axonemes-belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.

Original languageEnglish
Pages (from-to)1103-1114
Number of pages12
JournalBioScience
Volume64
Issue number12
Early online date25 Nov 2014
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Fingerprint Dive into the research topics of 'Eukaryotic flagella: Variations in form, function, and composition during evolution'. Together they form a unique fingerprint.

  • Cite this