Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC

M Harris Shoaib, Jaweria Tazeen, Hamid A Merchant, Rabia Ismail Yousuf

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

The aim of this study is to develop a once-daily sustained release matrix tablet of ibuprofen using hydroxypropyl methylcellulose (HPMC) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required sustained release profile tablets were directly compressed using Avicel pH 101 and Magnesium stearate. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model was based on linearity (coefficient of correlation). The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion.

LanguageEnglish
Pages119-24
Number of pages6
JournalPakistan Journal of Pharmaceutical Sciences
Volume19
Issue number2
Publication statusPublished - Apr 2006
Externally publishedYes

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Ibuprofen
Tablets
Pharmacokinetics
Complex Mixtures
Cellulose
Hypromellose Derivatives
Drug Liberation

Cite this

Shoaib, M Harris ; Tazeen, Jaweria ; Merchant, Hamid A ; Yousuf, Rabia Ismail. / Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. In: Pakistan Journal of Pharmaceutical Sciences. 2006 ; Vol. 19, No. 2. pp. 119-24.
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Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. / Shoaib, M Harris; Tazeen, Jaweria; Merchant, Hamid A; Yousuf, Rabia Ismail.

In: Pakistan Journal of Pharmaceutical Sciences, Vol. 19, No. 2, 04.2006, p. 119-24.

Research output: Contribution to journalArticle

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T1 - Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC

AU - Shoaib, M Harris

AU - Tazeen, Jaweria

AU - Merchant, Hamid A

AU - Yousuf, Rabia Ismail

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AB - The aim of this study is to develop a once-daily sustained release matrix tablet of ibuprofen using hydroxypropyl methylcellulose (HPMC) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required sustained release profile tablets were directly compressed using Avicel pH 101 and Magnesium stearate. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model was based on linearity (coefficient of correlation). The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion.

KW - Anti-Inflammatory Agents, Non-Steroidal/chemistry

KW - Chemistry, Pharmaceutical

KW - Delayed-Action Preparations

KW - Diffusion

KW - Hypromellose Derivatives

KW - Ibuprofen/chemistry

KW - Kinetics

KW - Methylcellulose/analogs & derivatives

KW - Models, Chemical

KW - Solubility

KW - Tablets

KW - Technology, Pharmaceutical/methods

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