Evaluation of Sesamum Gum as an Excipient in Matrix Tablets

Elijah I. Nep, Kofi Asare-Addo, N.c. Ngwuluka, Barbara Conway, Alan Smith

Research output: Contribution to journalArticle

Abstract

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.
Original languageEnglish
Pages (from-to)74-83
Number of pages10
JournalBritish Journal of Pharmacy
Volume1
DOIs
Publication statusPublished - 14 Nov 2016

Fingerprint

Sesamum
Excipients
Tablets
Theophylline
Modern 1601-history
Water
Africa South of the Sahara
Developing Countries
Buffers
Theoretical Models
Phosphates
Pharmaceutical Preparations
Population
Drug Liberation

Cite this

@article{f3fc38c225fc4c3cac3f9efdb9f50442,
title = "Evaluation of Sesamum Gum as an Excipient in Matrix Tablets",
abstract = "In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.",
keywords = "Sesame gum, Matrix, Sustained release, Sesamum radiatum",
author = "Nep, {Elijah I.} and Kofi Asare-Addo and N.c. Ngwuluka and Barbara Conway and Alan Smith",
year = "2016",
month = "11",
day = "14",
doi = "10.5920/bjpharm.2016.02",
language = "English",
volume = "1",
pages = "74--83",
journal = "British Journal of Pharmacy",
issn = "2058-8356",
publisher = "University of Huddersfield Press",

}

Evaluation of Sesamum Gum as an Excipient in Matrix Tablets. / Nep, Elijah I.; Asare-Addo, Kofi; Ngwuluka, N.c.; Conway, Barbara; Smith, Alan.

In: British Journal of Pharmacy, Vol. 1, 14.11.2016, p. 74-83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of Sesamum Gum as an Excipient in Matrix Tablets

AU - Nep, Elijah I.

AU - Asare-Addo, Kofi

AU - Ngwuluka, N.c.

AU - Conway, Barbara

AU - Smith, Alan

PY - 2016/11/14

Y1 - 2016/11/14

N2 - In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.

AB - In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.

KW - Sesame gum

KW - Matrix

KW - Sustained release

KW - Sesamum radiatum

U2 - 10.5920/bjpharm.2016.02

DO - 10.5920/bjpharm.2016.02

M3 - Article

VL - 1

SP - 74

EP - 83

JO - British Journal of Pharmacy

JF - British Journal of Pharmacy

SN - 2058-8356

ER -