Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats

Olumayokun A. Olajide, S. Olubusayo Awe, J. Modupe Makinde, Olugbenga Morebise

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The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg-1 of the extract at 4 h was 42.5 ± 0.4 mg/100 mL (control 67.4 ± 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg-1 extract fell to 51.9 ± 1.2, 47.3 ± 0.8, 43.1 ± 0.4 and 40.0 ± 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg-1 extract-treated animals having a plasma glucose level of 248.7 ± 5.3 mg/100 mL compared with glibenclamide (10 mg kg-1)-treated animals with a plasma glucose level of 251.5 ± 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.

Original languageEnglish
Pages (from-to)1321-1324
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Issue number11
Publication statusPublished - 1 Nov 1999
Externally publishedYes


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