TY - JOUR
T1 - Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats
AU - Olajide, Olumayokun A.
AU - Awe, S. Olubusayo
AU - Makinde, J. Modupe
AU - Morebise, Olugbenga
PY - 1999/11/1
Y1 - 1999/11/1
N2 - The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg-1 of the extract at 4 h was 42.5 ± 0.4 mg/100 mL (control 67.4 ± 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg-1 extract fell to 51.9 ± 1.2, 47.3 ± 0.8, 43.1 ± 0.4 and 40.0 ± 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg-1 extract-treated animals having a plasma glucose level of 248.7 ± 5.3 mg/100 mL compared with glibenclamide (10 mg kg-1)-treated animals with a plasma glucose level of 251.5 ± 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.
AB - The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg-1 of the extract at 4 h was 42.5 ± 0.4 mg/100 mL (control 67.4 ± 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg-1 extract fell to 51.9 ± 1.2, 47.3 ± 0.8, 43.1 ± 0.4 and 40.0 ± 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg-1 extract-treated animals having a plasma glucose level of 248.7 ± 5.3 mg/100 mL compared with glibenclamide (10 mg kg-1)-treated animals with a plasma glucose level of 251.5 ± 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.
UR - http://www.scopus.com/inward/record.url?scp=0033405682&partnerID=8YFLogxK
U2 - 10.1211/0022357991776903
DO - 10.1211/0022357991776903
M3 - Article
C2 - 10632091
AN - SCOPUS:0033405682
VL - 51
SP - 1321
EP - 1324
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 11
ER -