TY - JOUR
T1 - Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract
AU - Morebise, Olugbenga
AU - Awe, E. O.
AU - Modupe Makinde, J.
AU - Olajide, Olumayokun A.
PY - 2001/6/21
Y1 - 2001/6/21
N2 - A methanol extract of the dried leaves of Chasmanthera dependens was investigated for anti-inflammatory and analgesic activities. The extract (100-400 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. Furthermore, an inhibition in the leakage of Evan's blue induced by acetic acid was observed in mice. At same doses, analgesic effect was also observed on writhing response induced by acetic acid as well as on the early and late phase of formalin-induced paw licking in mice.
AB - A methanol extract of the dried leaves of Chasmanthera dependens was investigated for anti-inflammatory and analgesic activities. The extract (100-400 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. Furthermore, an inhibition in the leakage of Evan's blue induced by acetic acid was observed in mice. At same doses, analgesic effect was also observed on writhing response induced by acetic acid as well as on the early and late phase of formalin-induced paw licking in mice.
KW - Analgesic activity
KW - Anti-inflammatory activity
KW - Chasmanthera dependens
UR - http://www.scopus.com/inward/record.url?scp=0034950841&partnerID=8YFLogxK
U2 - 10.1016/S0367-326X(01)00274-X
DO - 10.1016/S0367-326X(01)00274-X
M3 - Article
C2 - 11429242
AN - SCOPUS:0034950841
VL - 72
SP - 497
EP - 502
JO - Fitoterapia
JF - Fitoterapia
SN - 0367-326X
IS - 5
ER -