Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract

Olugbenga Morebise, E. O. Awe, J. Modupe Makinde, Olumayokun A. Olajide

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A methanol extract of the dried leaves of Chasmanthera dependens was investigated for anti-inflammatory and analgesic activities. The extract (100-400 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. Furthermore, an inhibition in the leakage of Evan's blue induced by acetic acid was observed in mice. At same doses, analgesic effect was also observed on writhing response induced by acetic acid as well as on the early and late phase of formalin-induced paw licking in mice.

LanguageEnglish
Pages497-502
Number of pages6
JournalFitoterapia
Volume72
Issue number5
DOIs
Publication statusPublished - 21 Jun 2001
Externally publishedYes

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Non-Steroidal Anti-Inflammatory Agents
Acetic Acid
Methanol
Evans Blue
Carrageenan
Granuloma
Formaldehyde
Analgesics
Edema

Cite this

Morebise, Olugbenga ; Awe, E. O. ; Modupe Makinde, J. ; Olajide, Olumayokun A. / Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract. In: Fitoterapia. 2001 ; Vol. 72, No. 5. pp. 497-502.
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Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract. / Morebise, Olugbenga; Awe, E. O.; Modupe Makinde, J.; Olajide, Olumayokun A.

In: Fitoterapia, Vol. 72, No. 5, 21.06.2001, p. 497-502.

Research output: Contribution to journalArticle

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