Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract

Olugbenga Morebise, E. O. Awe, J. Modupe Makinde, Olumayokun A. Olajide

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A methanol extract of the dried leaves of Chasmanthera dependens was investigated for anti-inflammatory and analgesic activities. The extract (100-400 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. Furthermore, an inhibition in the leakage of Evan's blue induced by acetic acid was observed in mice. At same doses, analgesic effect was also observed on writhing response induced by acetic acid as well as on the early and late phase of formalin-induced paw licking in mice.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
Issue number5
Publication statusPublished - 21 Jun 2001
Externally publishedYes


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