Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht & Cham) scrophulariacae

E. O. Awe, J. M. Makinde, O. A. Olajide, O. K. Wakeel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A methanolic extract of Russelia equisetiformis whole plant was studied for anti-inflammatory and analgesic activities in rats and mice using carrageenan-induced rat paw oedema, acetic-acid-induced writhing and tail-flick test. The extract, at 10, 20 and 40 mg/kg, significantly (P < 0.05) inhibited carrageenan-induced oedema in rats. Abdominal constriction induced by acetic acid was also inhibited by the extract, within the same dose range. The extract at the same dose also prolonged the latency period in the tail-flick response test, which was reverted by naloxone. The results suggested that the extract possesses potential anti-inflammatory and analgesic properties.

LanguageEnglish
Pages399-405
Number of pages7
JournalInflammopharmacology
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Dec 2004
Externally publishedYes

Fingerprint

Non-Steroidal Anti-Inflammatory Agents
Carrageenan
Acetic Acid
Tail
Edema
Naloxone
Constriction

Cite this

@article{b2dd0bface99480ea58cc8b37bbe26df,
title = "Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht & Cham) scrophulariacae",
abstract = "A methanolic extract of Russelia equisetiformis whole plant was studied for anti-inflammatory and analgesic activities in rats and mice using carrageenan-induced rat paw oedema, acetic-acid-induced writhing and tail-flick test. The extract, at 10, 20 and 40 mg/kg, significantly (P < 0.05) inhibited carrageenan-induced oedema in rats. Abdominal constriction induced by acetic acid was also inhibited by the extract, within the same dose range. The extract at the same dose also prolonged the latency period in the tail-flick response test, which was reverted by naloxone. The results suggested that the extract possesses potential anti-inflammatory and analgesic properties.",
keywords = "Analgesic, Anti-inflammatory, Mouse, Rat, Russelia equisetiformis extract",
author = "Awe, {E. O.} and Makinde, {J. M.} and Olajide, {O. A.} and Wakeel, {O. K.}",
year = "2004",
month = "12",
day = "1",
doi = "10.1163/1568560043696245",
language = "English",
volume = "12",
pages = "399--405",
journal = "Inflammopharmacology",
issn = "0925-4692",
publisher = "Birkhauser Verlag Basel",
number = "4",

}

Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht & Cham) scrophulariacae. / Awe, E. O.; Makinde, J. M.; Olajide, O. A.; Wakeel, O. K.

In: Inflammopharmacology, Vol. 12, No. 4, 01.12.2004, p. 399-405.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht & Cham) scrophulariacae

AU - Awe, E. O.

AU - Makinde, J. M.

AU - Olajide, O. A.

AU - Wakeel, O. K.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - A methanolic extract of Russelia equisetiformis whole plant was studied for anti-inflammatory and analgesic activities in rats and mice using carrageenan-induced rat paw oedema, acetic-acid-induced writhing and tail-flick test. The extract, at 10, 20 and 40 mg/kg, significantly (P < 0.05) inhibited carrageenan-induced oedema in rats. Abdominal constriction induced by acetic acid was also inhibited by the extract, within the same dose range. The extract at the same dose also prolonged the latency period in the tail-flick response test, which was reverted by naloxone. The results suggested that the extract possesses potential anti-inflammatory and analgesic properties.

AB - A methanolic extract of Russelia equisetiformis whole plant was studied for anti-inflammatory and analgesic activities in rats and mice using carrageenan-induced rat paw oedema, acetic-acid-induced writhing and tail-flick test. The extract, at 10, 20 and 40 mg/kg, significantly (P < 0.05) inhibited carrageenan-induced oedema in rats. Abdominal constriction induced by acetic acid was also inhibited by the extract, within the same dose range. The extract at the same dose also prolonged the latency period in the tail-flick response test, which was reverted by naloxone. The results suggested that the extract possesses potential anti-inflammatory and analgesic properties.

KW - Analgesic

KW - Anti-inflammatory

KW - Mouse

KW - Rat

KW - Russelia equisetiformis extract

UR - http://www.scopus.com/inward/record.url?scp=21344472133&partnerID=8YFLogxK

U2 - 10.1163/1568560043696245

DO - 10.1163/1568560043696245

M3 - Article

VL - 12

SP - 399

EP - 405

JO - Inflammopharmacology

T2 - Inflammopharmacology

JF - Inflammopharmacology

SN - 0925-4692

IS - 4

ER -