TY - JOUR
T1 - Evaluation of the anti-inflammatory properties of Chlorophora excelsa stem bark extract
AU - Olajide, Olumayokun A.
AU - Kolawole, Oyetunji T.
AU - Fagbohun, Temitope R.
AU - Ajayi, Franklin F.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - A methanol extract of the stem bark of Chlorophora excelsa (Welw.) Benth and Hook was evaluated for anti-inflammatory activity in different models. Acute inflammatory effects were studied in the carrageenan-induced rat paw edema, and the effect of the extract in chronic inflammation was evaluated using the cotton pellet granuloma test. The effect of the extract on topical inflammation induced with croton oil was also tested in mice. The extract produced a significant (p. < 0.05) and dose-dependent inhibition of the carrageenan-induced pedal edema, as well as granuloma tissue formation in rats. Topical anti-inflammatory effect was only evident with 400 mg/kg of the extract. This study demonstrated acute, chronic, and topical anti-inflammatory properties of the methanol extract of C. excelsa.
AB - A methanol extract of the stem bark of Chlorophora excelsa (Welw.) Benth and Hook was evaluated for anti-inflammatory activity in different models. Acute inflammatory effects were studied in the carrageenan-induced rat paw edema, and the effect of the extract in chronic inflammation was evaluated using the cotton pellet granuloma test. The effect of the extract on topical inflammation induced with croton oil was also tested in mice. The extract produced a significant (p. < 0.05) and dose-dependent inhibition of the carrageenan-induced pedal edema, as well as granuloma tissue formation in rats. Topical anti-inflammatory effect was only evident with 400 mg/kg of the extract. This study demonstrated acute, chronic, and topical anti-inflammatory properties of the methanol extract of C. excelsa.
KW - Acute inflammation
KW - Anti-inflammatory
KW - Chlorophora excelsa
KW - Chronic inflammation
KW - Extract
KW - Topical inflammation
UR - http://www.scopus.com/inward/record.url?scp=33644769053&partnerID=8YFLogxK
U2 - 10.1080/13880200500406388
DO - 10.1080/13880200500406388
M3 - Article
AN - SCOPUS:33644769053
VL - 43
SP - 746
EP - 748
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
SN - 1388-0209
IS - 9
ER -