Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)

Olumayokun A. Olajide, J. Modupe Makinde, David T. Okpako

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalInflammopharmacology
Volume11
Issue number3
DOIs
Publication statusPublished - 22 Sep 2003
Externally publishedYes

Fingerprint

Combretum
Combretaceae
Anti-Inflammatory Agents
Carrageenan
Capillary Permeability
Granuloma
Acetic Acid
Edema
Indomethacin
Methanol
Inflammation
Injections

Cite this

@article{e544774444b4459bab19069999fb5c7f,
title = "Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)",
abstract = "A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.",
keywords = "Anti-inflammatory, Combretum micranthum, Extract, Mice, Rats",
author = "Olajide, {Olumayokun A.} and Makinde, {J. Modupe} and Okpako, {David T.}",
year = "2003",
month = "9",
day = "22",
doi = "10.1163/156856003322315631",
language = "English",
volume = "11",
pages = "293--298",
journal = "Inflammopharmacology",
issn = "0925-4692",
publisher = "Birkhauser Verlag Basel",
number = "3",

}

Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae). / Olajide, Olumayokun A.; Makinde, J. Modupe; Okpako, David T.

In: Inflammopharmacology, Vol. 11, No. 3, 22.09.2003, p. 293-298.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)

AU - Olajide, Olumayokun A.

AU - Makinde, J. Modupe

AU - Okpako, David T.

PY - 2003/9/22

Y1 - 2003/9/22

N2 - A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.

AB - A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.

KW - Anti-inflammatory

KW - Combretum micranthum

KW - Extract

KW - Mice

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=0041821322&partnerID=8YFLogxK

U2 - 10.1163/156856003322315631

DO - 10.1163/156856003322315631

M3 - Article

VL - 11

SP - 293

EP - 298

JO - Inflammopharmacology

JF - Inflammopharmacology

SN - 0925-4692

IS - 3

ER -