Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)

Olumayokun A. Olajide, J. Modupe Makinde, David T. Okpako

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalInflammopharmacology
Volume11
Issue number3
DOIs
Publication statusPublished - 22 Sep 2003
Externally publishedYes

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