Evaluation of the pharmacological properties of nutmeg oil in rats and mice

O. A. Olajide, J. M. Makinde, S. O. Awe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pharmacological properties of nutmeg oil in animal models were investigated. The oil exhibited an anti-inflammatory effect on acute inflammation. An analgesic effect was produced by the oil in the acetic acid-induced writhing model and in the late phase of the formalin-induced licking. The oil showed an antipyretic activity, and antithrombotic and anti-diarrhoeal properties. Sub-acute administration of the oil produced gastric ulcerations. These data indicate that nutmeg oil showed pharmacological activities similar to those of non-steroidal anti-inflammatory drugs, in addition to anti-diarrhoeal activity.

LanguageEnglish
Pages385-390
Number of pages6
JournalPharmaceutical Biology
Volume38
Issue number5
DOIs
Publication statusPublished - 1 Dec 2000
Externally publishedYes

Fingerprint

Myristica fragrans
Oils
Pharmacology
Anti-Inflammatory Agents
Antipyretics
Acetic Acid
Formaldehyde
Analgesics
Stomach
Animal Models
Inflammation
Pharmaceutical Preparations

Cite this

Olajide, O. A. ; Makinde, J. M. ; Awe, S. O. / Evaluation of the pharmacological properties of nutmeg oil in rats and mice. In: Pharmaceutical Biology. 2000 ; Vol. 38, No. 5. pp. 385-390.
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Evaluation of the pharmacological properties of nutmeg oil in rats and mice. / Olajide, O. A.; Makinde, J. M.; Awe, S. O.

In: Pharmaceutical Biology, Vol. 38, No. 5, 01.12.2000, p. 385-390.

Research output: Contribution to journalArticle

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