Evaluation of the pharmacological properties of nutmeg oil in rats and mice

O. A. Olajide, J. M. Makinde, S. O. Awe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pharmacological properties of nutmeg oil in animal models were investigated. The oil exhibited an anti-inflammatory effect on acute inflammation. An analgesic effect was produced by the oil in the acetic acid-induced writhing model and in the late phase of the formalin-induced licking. The oil showed an antipyretic activity, and antithrombotic and anti-diarrhoeal properties. Sub-acute administration of the oil produced gastric ulcerations. These data indicate that nutmeg oil showed pharmacological activities similar to those of non-steroidal anti-inflammatory drugs, in addition to anti-diarrhoeal activity.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalPharmaceutical Biology
Volume38
Issue number5
DOIs
Publication statusPublished - 1 Dec 2000
Externally publishedYes

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