Evolution of cardiorespiratory interactions with age

D. Iatsenko, A. Bernjak, T. Stankovski, Y. Shiogai, P. J. Owen-Lynch, P. B.M. Clarkson, P. V.E. McClintock, A. Stefanovska

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms.We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

Original languageEnglish
Article number20110622
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume371
Issue number1997
DOIs
Publication statusPublished - 28 Aug 2013
Externally publishedYes

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Interaction
Cardiac
Wavelet transforms
Time series
Synchronization
Age Dependence
Modulation
interactions
heart rate
time functions
respiration
Heart Rate
Time Dependence
Respiration
Coupled Oscillators
Bayesian inference
inference
wavelet analysis
Wavelet Transform
time dependence

Cite this

Iatsenko, D. ; Bernjak, A. ; Stankovski, T. ; Shiogai, Y. ; Owen-Lynch, P. J. ; Clarkson, P. B.M. ; McClintock, P. V.E. ; Stefanovska, A. / Evolution of cardiorespiratory interactions with age. In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2013 ; Vol. 371, No. 1997.
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Iatsenko, D, Bernjak, A, Stankovski, T, Shiogai, Y, Owen-Lynch, PJ, Clarkson, PBM, McClintock, PVE & Stefanovska, A 2013, 'Evolution of cardiorespiratory interactions with age', Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 371, no. 1997, 20110622. https://doi.org/10.1098/rsta.2011.0622

Evolution of cardiorespiratory interactions with age. / Iatsenko, D.; Bernjak, A.; Stankovski, T.; Shiogai, Y.; Owen-Lynch, P. J.; Clarkson, P. B.M.; McClintock, P. V.E.; Stefanovska, A.

In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 371, No. 1997, 20110622, 28.08.2013.

Research output: Contribution to journalArticle

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